1450916-28-5 Usage
Description
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile is a chiral compound characterized by a cyclopropane ring, a carbonitrile functional group, and two fluorine atoms attached to the phenyl group. Its unique structure, with two carbon substituents in a cis configuration, may contribute to potential biological activity and applications.
Uses
Used in Pharmaceutical Industry:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile is used as a potential pharmaceutical compound for its unique structure and possible biological activity. Its chiral nature and functional groups may offer advantages in drug design and development.
Used in Organic Synthesis:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile is used as a building block in organic synthesis for the preparation of various compounds. Its cyclopropane ring and functional groups can be utilized in the synthesis of complex organic molecules for different applications.
Further research and testing are required to fully understand the properties and potential applications of (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1450916-28-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,9,1 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1450916-28:
(9*1)+(8*4)+(7*5)+(6*0)+(5*9)+(4*1)+(3*6)+(2*2)+(1*8)=155
155 % 10 = 5
So 1450916-28-5 is a valid CAS Registry Number.
1450916-28-5Relevant articles and documents
Novel synthesis method of ticagrelor intermediate (1R,2R)-2-(3,4-difluorophenyl) cyclopropane nitrile
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Paragraph 0052; 0053, (2017/10/25)
The invention discloses a novel synthesis method of a ticagrelor intermediate (1R,2R)-2-(3,4-difluorophenyl) cyclopropane nitrile. The novel synthesis method comprises the following steps: firstly, carrying out amination reaction on a glucose molecule chiral auxiliary reagent and (2E)-3-(3,4-diflurophenyl) acryloyl chloride; secondly, carrying out cyclopropanation reaction on a reactant and a sulfur ylide reagent to obtain a N-glucosyl (1R,2R)-2-(3,4-diflurophenyl) cyclopropanecarboxamide; thirdly, carrying out beta-N-glycosylation reaction on the N-glucosyl(1R,2R)-2-(3,4-diflurophenyl) cyclopropanecarboxamide under the action of PPh3, CBr4, AgOTf and NH3 water. The novel method has the characteristics of shorter process route, low-priced and easily-obtained starting materials, high yield, good stereoselectivity, good enantioselectivity and the like; the production cost is reduced to a great extent and better benefits in economy are obtained.
PREPARATION OF TICAGRELOR
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, (2015/03/16)
Provided are processes for preparing Ticagrelor and its intermediates that are useful in the processes. Also provided are salts of Ticagrelor, their processes and solid dispersion of Ticagrelor having Ticagrelor in amorphous form.
