1334600-89-3

Basic information

• Product Name: 7-morpholin-4-yl-4-((S)-3-phenyl-piperidin-1-yl)-quinazoline
• CAS NO: 1334600-89-3
• Molecular Weight: 374.486
• Mol File: 1334600-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-morpholin-4-yl-4-((S)-3-phenyl-piperidin-1-yl)-quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-morpholin-4-yl-4-((S)-3-phenyl-piperidin-1-yl)-quinazoline(1334600-89-3)
• EPA Substance Registry System: 7-morpholin-4-yl-4-((S)-3-phenyl-piperidin-1-yl)-quinazoline(1334600-89-3)

Safety Data

• Hazardous Substances Data: 1334600-89-3(Hazardous Substances Data)

Upstream product

• 194851-16-6 7-bromoquinazolin-4(3H)-one 
• 16499-57-3 7-fluoro-3H-quinazolin-4-one 
• 404010-74-8 2-amino-4-(morpholin-4-yl)benzoic acid 
• 1265848-98-3 7-morpholin-4-yl-3H-quinazolin-4-one 
• 1334602-76-4 4-(4-methoxybenzyloxy)-7-morpholin-4-yl-quinazoline 
• 446-32-2 4-fluoroanthranilic acid 
• 1334602-75-3 7-bromo-4-((4-methoxybenzyl)oxy)quinazoline 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 573675-55-5 7-bromo-4-chloro-quinazoline 

Relevant articles and documents

Morpholinylquinazolines

The invention relates to compounds of the formulae (I), (II) and (III) in which R1, R2, R3, R4, Y, W1, W2, L, A, Alk, Cyc, Ar, Het1, Het2, Hal and n have the meaning indicated in claim 1, and/or physiologically acceptable salts, tautomers and stereo-isomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of their salts.