13395-60-3

Basic information

• Product Name: 3-chloro-4'-methylbenzophenone
• Synonyms: Benzophenone,3-chloro-4'-methyl- (8CI); 3-Chloro-4'-methylbenzophenone
• CAS NO: 13395-60-3
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.7
• Mol File: 13395-60-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 368.5°Cat760mmHg
• Flash Point: 198.8°C
• Appearance: /
• Density: 1.178g/cm³
• CAS DataBase Reference: 3-chloro-4'-methylbenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4'-methylbenzophenone(13395-60-3)
• EPA Substance Registry System: 3-chloro-4'-methylbenzophenone(13395-60-3)

Safety Data

• Hazardous Substances Data: 13395-60-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-4'-methylbenzophenone, also known as 4-methyl-3-chlorobenzophenone, is a chemical compound with the molecular formula C14H11ClO. It is a white solid with a melting point of 47-48°C and a boiling point of 332°C. 3-chloro-4'-methylbenzophenone is used as a UV absorber in the production of plastics and polymers, as well as in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as an intermediate in the manufacturing of dyes, perfumes, and other organic compounds. However, it is important to handle this chemical with caution as it is considered harmful if swallowed, inhaled, or in contact with skin, and it may cause irritation to the eyes and respiratory system.

Upstream product

• 618-46-2 m-Chlorobenzoyl chloride 
• 108-88-3 toluene 
• 874-60-2 4-methyl-benzoyl chloride 
• 108-90-7 chlorobenzene 
• 535-80-8 3-chlorobenzoate 
• 624742-95-6 3-(4'-methylbenzoyl)phenyl radical 
• 106-38-7 para-bromotoluene 
• 587-04-2 m-Chlorobenzaldehyde 
• 63503-60-6 3-chlorophenylboronic acid 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 945657-22-7 (4-bromomethyl-phenyl)(3-chloro-phenyl)methanone 
• 898776-32-4 (3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanone 
• 927690-10-6 (+/-)-(3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]phenylmethanol 
• 949934-32-1 (3-chlorophenyl){4-[(N-tert-butoxycarbonylpiperazin-4-yl)methyl]phenyl}methanol 
• 949934-31-0 (3-chlorophenyl){4-[(N-tert-butoxycarbonylpiperazin-4-yl)methyl]phenyl}methanone 
• 1014987-03-1 tert-butyl 4-(4-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)benzyl)piperazine-1-carboxylate 
• 949934-34-3 C₂₃H₂₈Cl₂N₂O₂*ClH 

Relevant articles and documents

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An Effective Osmium Precatalyst for Practical Synthesis of Diarylketones: Preparation, Reactivity, and Catalytic Application of [OsH- cis-(CO)2- mer-{κ3- P, B, P′-B(NCH2PPh2)2- o-C6H4}]

Developing new approaches for efficient synthesis of diarylketones from commercially available inexpensive substrates via practical procedures is highly desirable. In this work, an effective catalytic system for the synthesis of diarylketones was developed based on a newly synthesized Os PBP pincer complex [OsH-cis-(CO)2-mer-{κ3-P,B,P′-B(NCH2PPh2)2-o-C6H4}] (1). Complex 1 proved to be very stable against many reagents at room temperature; CS2 can only react with 1 at elevated temperatures to produce [Os(κ2-S,S'-S2CH)(CO)-mer-{κ3-P,B,P′-B(NCH2PPh2)2-o-C6H4}] (2). Complex 1 was found to be an efficient precatalyst for the coupling reactions between arylboronic acids and aryl aldehydes. The reactions are tolerant of many functional groups and proceed smoothly in toluene in the presence of K3PO4 and H2O at 100 °C under an air atmosphere to give diaryl ketones in good to excellent yields. It was demonstrated that the reactions were catalyzed by in situ generated osmium nanoparticles. This work would open an avenue of heterogeneous transition metal catalyst system for the synthesis of diarylketones via the coupling reactions between arylboronic acids and aryl aldehydes, which has never been reported before.

NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS

The present invention relates to clotrimazole/quinoline hybrids useful as active ingredients of anti-malaria drugs. The compounds show a remarkable in vitro biological activity especially against the chloroquine-resistant Plasmodium falciparum strains and