13420-63-8 Usage
Description
2-chloro-6-iodobenzoic acid is an organic compound characterized by the presence of a chlorine atom at the 2nd position and an iodine atom at the 6th position on a benzoic acid molecule. It is a versatile building block in organic synthesis and has potential applications in various industries due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
2-chloro-6-iodobenzoic acid is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows for further functionalization and modification, making it a valuable starting material for the synthesis of various drug candidates.
Used in Chemical Research:
In the field of chemical research, 2-chloro-6-iodobenzoic acid serves as a key building block for the exploration of novel chemical reactions and the development of innovative synthetic methods. Its reactivity and structural properties make it an attractive candidate for studying new reaction mechanisms and improving existing synthetic routes.
Used in Material Science:
2-chloro-6-iodobenzoic acid can be utilized as a component in the development of new materials with specific properties, such as optoelectronic materials or advanced polymers. Its unique structure can contribute to the desired characteristics of these materials, making it a valuable asset in material science research and development.
Synthesis Method:
The synthesis of 2-chloro-6-iodobenzoic acid involves a C-H activation method developed by Yu and coworkers. This method employs the Yu-Wasa Auxiliary (Aldrich 791806) and I2 as the sole oxidant for ortho-iodination from the corresponding benzoic acid derivative. This innovative approach allows for the efficient and selective synthesis of 2-chloro-6-iodobenzoic acid, making it more accessible for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 13420-63-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,2 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13420-63:
(7*1)+(6*3)+(5*4)+(4*2)+(3*0)+(2*6)+(1*3)=68
68 % 10 = 8
So 13420-63-8 is a valid CAS Registry Number.
13420-63-8Relevant articles and documents
Ortholithiation of unprotected benzoic acids: Application for novel 2-chloro-6-substituted benzoic acid syntheses
Gohier, Frederic,Castanet, Anne-Sophie,Mortier, Jacques
, p. 799 - 806 (2005)
2-Chloro-6-substituted benzoic acids of the type 2a-h were prepared by the tandem metallation sequence from 2-chlorobenzoic acid 1 with the 1:1 complex secbutyllithium/TMEDA in THF at -78°C followed by quenching with electrophiles.
Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations
Erbing, Elis,Sanz-Marco, Amparo,Vázquez-Romero, Ana,Malmberg, Jesper,Johansson, Magnus J.,Gómez-Bengoa, Enrique,Martín-Matute, Belén
, p. 920 - 925 (2018/02/14)
A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group.
TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS
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Page/Page column 89; 90, (2014/01/08)
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
