134206-11-4

Basic information

• Product Name: (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester
• Synonyms: (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester
• CAS NO: 134206-11-4
• Molecular Weight: 383.444
• Mol File: 134206-11-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester(134206-11-4)
• EPA Substance Registry System: (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester(134206-11-4)

Safety Data

• Hazardous Substances Data: 134206-11-4(Hazardous Substances Data)

Upstream product

• 17831-01-5 H-Ala-OBzl 
• 15121-89-8 ethyl (E)-4-oxo-4-phenyl-2-butenoate 
• 42854-62-6 L-alanine benzyl ester p-toluenesulfonate 

Downstream Products

• 84324-12-9 N-<1(R)-(ethoxycarbonyl)-3-phenylpropyl>-(S)-alanine 

Relevant articles and documents

Addition of enantiomerically pure amines to activated olefines II. On the addition to ethyl (E)-4-oxo-4-phenyl-2-butenoate

The addition of (S)-phenethylamine to ethyl (E)-4-oxo-4-phenyl-2-butenoate shows no kinetic selectivity, whereas - according to the b,pl,H-rule the AB-and BB-product are kinetically preferred in the addition of (S)-alanine-isopropylester and -benzylester,

A FAVOURABLE DIASTEREOSELECTIVE SYNTHESIS OF N-(1-S-ETHOXYCARBONYL-3-PHENYLPROPYL)-S-ALANINE

N-(1-S-Ethoxycarbonyl-3-phenylpropyl)-S-alanine is prepared by Michael addition of S-alaninebenzylester to ethyl-4-oxo-4-phenyl-2-butenoate in a regio- and diastereoselective fashion and subsequent catalytic hydrogenolysis.