84324-12-9

Basic information

• Product Name: (-)-N-[1-(R)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine
• Synonyms: (+)-N-[1-(R)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine;N-[(R)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine;(αR)-α-[[(1S)-1-carboxyethyl]aMino]benzenebutanoic Acid;RaMipril IMpurity-F
• CAS NO: 84324-12-9
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.33154
• Product Categories: Amino Acids & Derivatives;Aromatics;Chiral Reagents;Intermediates
• Mol File: 84324-12-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 145-147°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Acetone (Slightly, Heated), Methanol (Slightly, Sonicated)
• CAS DataBase Reference: (-)-N-[1-(R)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-N-[1-(R)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine(84324-12-9)
• EPA Substance Registry System: (-)-N-[1-(R)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine(84324-12-9)

Safety Data

• Hazardous Substances Data: 84324-12-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Ramipril.

Upstream product

• 93841-86-2 N-<1(R)-(Ethoxycarbonyl)-3-phenylpropyl>-(S)-alanin-benzylester 
• 134206-11-4 (1'S,2R)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester 
• 80828-28-0 N-<(R)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanine tert-butylester 
• 93836-43-2 (R)-benzyl α-trifluoromethanesulphonyloxy propanoate 
• 124044-66-2 (R)-ethyl 2-amino-4-phenylbutanoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 120379-81-9 5-phenylethyl-imidazolidine-2,4-dione 
• 121842-76-0 (R)-2-bromo-4-phenylbutyric acid 
• 121842-77-1 (R)-ethyl 2-bromo-4-phenylbutyrate 
• 121842-75-9 N-carbamyl (R)-2-amino-4-phenylbutyric acid 
• 15121-89-8 ethyl (E)-4-oxo-4-phenyl-2-butenoate 
• 93921-85-8 ethyl 2-hydroxy-4-phenylbutanoate 
• 90365-91-6 (-)-α-[(Trifluoromethyl)sulfonyl]oxy-4-phenylbutyric acid,ethyl ester 

Downstream Products

• 90891-24-0 (R)-2-[(S)-1-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-ethylamino]-4-phenyl-butyric acid ethyl ester 
• 80828-33-7 (2S,3aS,7aS)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 80828-33-7 (2R,3aR,7aR)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 121209-29-8 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid 
• 83507-88-4 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid 

Relevant articles and documents

Purification method of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanine

The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application. An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.

A practical and diastereoselective synthesis of angiotensin converting enzyme inhibitors

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