134227-45-5

Basic information

• Product Name: 3,4,5-TRIFLUOROBENZONITRILE
• Synonyms: 3,4,5-TRIFLUOROBENZONITRILE;3,4,5-TRIFLUORO-1-CYANO BENZENE;3,4,5-Trifluorobenzonitrile, 97+%;Benzonitrile, 3,4,5-trifluoro- (9CI);3-flurophenylacetic acid;3,4,5-Trifluorobenzonitrile 99%;3,4,5-Trifluorobenzonitrile99%;3,4,5-Trifluorobenzo
• CAS NO: 134227-45-5
• Molecular Formula: C₇H₂F₃N
• Molecular Weight: 157.09
• Product Categories: HALIDE;Aromatic Nitriles;Nitrile;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Fluorine series;Heterocyclic Acids,Thiophenes ,Thiazolines/Thiazolidines
• Mol File: 134227-45-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 45-47 °C(lit.)
• Boiling Point: 72-73 °C10 mm Hg(lit.)
• Flash Point: 145 °F
• Appearance: semi-transparent crystals
• Density: 1.2465 (estimate)
• Vapor Pressure: 0.541mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• BRN: 7702244
• CAS DataBase Reference: 3,4,5-TRIFLUOROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIFLUOROBENZONITRILE(134227-45-5)
• EPA Substance Registry System: 3,4,5-TRIFLUOROBENZONITRILE(134227-45-5)

Safety Data

• Hazard Codes: F,T,Xi,Xn
• Statements: 11-36/37/38-20/21/22
• Safety Statements: 16-33-36-26-36/37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 134227-45-5(Hazardous Substances Data)

Usage

Chemical Properties

semi-transparent crystals

InChI:InChI=1/C7H2F3N/c8-5-1-4(3-11)2-6(9)7(5)10/h1-2H

Upstream product

• 544-92-3 copper(I) cyanide 
• 138526-69-9 3,4,5-trifluoro-1-bromobenzene 
• 132123-54-7 3,4,5-trifluorobenzaldehyde 

Downstream Products

• 104197-15-1 3,5-difluoro-4-methoxybenzonitrile 
• 298211-16-2 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile 
• 235088-69-4 (3,4,5-trifluorophenyl)methanamine 
• 735330-92-4 3,5-difluoro-4-azepan-1-ylbenzonitrile 
• 735330-95-7 4-(8-azabicyclo[3.2.1]oct-8-yl)-3,5-difluorobenzonitrile 
• 581813-07-2 3,5-difluoro-4-(4-morpholinyl)benzylamine 
• 298211-09-3 di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate 
• 298211-18-4 2-{4-[bis-(2-hydroxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 298211-10-6 di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate 
• 298211-08-2 di-tert-butyl (3,5-difluoro-4-[bis(2-iodoethyl)amino]benzoyl)-L-glutamate 
• 298211-19-5 2-{4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 694503-97-4 3,5-difluoro-4-[bis(2-tetrahydropyranyloxyethyl)amino]benzoic acid 
• 694503-98-5 3,5-difluoro-4-[bis(2-tetrahydropyranyloxyethyl)amino]benzoyl azide 

Related news

Chelating phosphines by nucleophilic substitution of fluorine in 3,4,5-TRIFLUOROBENZONITRILE (cas 134227-45-5) and tetrafluorophthalonitrile07/24/2019

Directed nucleophilic substitution of two fluorine atoms in title compounds 1, 2 by diphenylphosphine groups was used to prepare new chelating electron-deficient diphosphine ligands 3 and 4 ; the structure of 4 was confirmed by XRD analysisdetailed

Relevant articles and documents

Stable and reusable nanoscale Fe2O3-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides

The sustainable introduction of nitrogen moieties in the form of nitrile or amide groups in functionalized molecules is of fundamental interest because nitrogen-containing motifs are found in a large number of life science molecules, natural products and materials. Hence, the synthesis and functionalization of nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein we report the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O2 or air. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process proceeds to synthesise functionalized and structurally diverse aromatic, aliphatic and heterocyclic nitriles. Additionally, applying this iron-based protocol, primary amides have also been prepared in a water medium.

AMIDE COMPOUNDS AND THEIR USE

Since an amide compound represented by the formula (1) is effectiveness for controlling plant diseases, it is useful as an effective ingredient of a composition for controlling plant diseases.

CYCLIC AMINE COMPOUND

A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.