298211-16-2

Basic information

• Product Name: 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile
• Synonyms: 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile
• CAS NO: 298211-16-2
• Molecular Weight: 242.225
• Mol File: 298211-16-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile(298211-16-2)
• EPA Substance Registry System: 4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile(298211-16-2)

Safety Data

• Hazardous Substances Data: 298211-16-2(Hazardous Substances Data)

Upstream product

• 111-42-2 2,2'-iminobis[ethanol] 
• 134227-45-5 3,4,5-trifluorobenzonitrile 

Downstream Products

• 694503-98-5 3,5-difluoro-4-[bis(2-tetrahydropyranyloxyethyl)amino]benzoyl azide 
• 694503-97-4 3,5-difluoro-4-[bis(2-tetrahydropyranyloxyethyl)amino]benzoic acid 
• 298211-17-3 3,5-difluoro-4-[bis(2-hydroxyethyl)amino]benzoic acid 
• 298211-19-5 2-{4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 298211-08-2 di-tert-butyl (3,5-difluoro-4-[bis(2-iodoethyl)amino]benzoyl)-L-glutamate 
• 298211-10-6 di-tert-butyl {4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamate 
• 298211-18-4 2-{4-[bis-(2-hydroxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 298211-09-3 di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate 

Relevant articles and documents

NITROGEN MUSTARD COMPOUNDS AND PRODRUGS THEREFOR

This invention pertains to nitrogen mustard compounds (Formula (II)) and prodrugs therefor (Formula (I)), methods for their preparation, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro a

Significant Differences in Biological Parameters between Prodrugs Cleavable by Carboxypeptidase G2 That Generate 3,5-Difluoro-phenol and -aniline Nitrogen Mustards in Gene-Directed Enzyme Prodrug Therapy Systems

Nine new nitrogen mustard compounds derived from 2,6-difluoro-4-hydroxy- (3a-e) and 2,6-difluoro-4-amino- (4a-d) aniline were synthesized as potential prodrugs. They were designed to be activated to their corresponding 3,5-difluorophenol and -aniline (4)-