134517-56-9 Usage
Description
2,4-dichloro-5-trifluoromethylquinazoline is a quinazoline derivative with the molecular formula C10H5Cl2F3N2. It is a highly fluorinated and chlorinated molecule, featuring two chlorine atoms and three fluorine atoms attached to a quinazoline ring. This unique structure and functional groups endow it with potential applications in various fields, including medicinal chemistry, agricultural chemicals, and material science.
Uses
Used in Medicinal Chemistry:
2,4-dichloro-5-trifluoromethylquinazoline is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure and functional groups make it a promising candidate for the development of new drugs with improved potency and selectivity.
Used in Agricultural Chemicals:
In the agricultural industry, 2,4-dichloro-5-trifluoromethylquinazoline is used as a precursor for the development of novel agrochemicals. Its potential as a building block for the synthesis of new pesticides or herbicides is currently under investigation.
Used in Material Science:
2,4-dichloro-5-trifluoromethylquinazoline is utilized as a component in the development of advanced materials. Its unique properties, such as high fluorination and chlorination, make it suitable for applications in areas like polymer science, where it can contribute to the creation of new materials with enhanced properties.
The precise properties and potential uses of 2,4-dichloro-5-trifluoromethylquinazoline are the subject of ongoing research and exploration, as its full potential in various industries is yet to be fully realized.
Check Digit Verification of cas no
The CAS Registry Mumber 134517-56-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,5,1 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 134517-56:
(8*1)+(7*3)+(6*4)+(5*5)+(4*1)+(3*7)+(2*5)+(1*6)=119
119 % 10 = 9
So 134517-56-9 is a valid CAS Registry Number.
134517-56-9Relevant articles and documents
Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H4 Receptor Inverse Agonists
Smits, Rogier A.,Adami, Maristella,Istyastono, Enade P.,Zuiderveld, Obbe P.,Van Dam, Cindy M. E.,De Kanter, Frans J. J.,Jongejan, Aldo,Coruzzi, Gabriella,Leurs, Rob,De Esch, Iwan J. P.
supporting information; experimental part, p. 2390 - 2400 (2010/09/11)
Hit optimization of the class of quinazoline containing histamine H 4 receptor (H4R) ligands resulted in a sulfonamide substituted analogue with high affinity for the H4R. This moiety leads to improved physicochemical properties and is believed to probe a distinct H4R binding pocket that was previously identified using pharmacophore modeling. By introducing a variety of sulfonamide substituents, the H4R affinity was optimized. The interaction of the new ligands, in combination with a set of previously published quinazoline compounds, was described by a QSAR equation. Pharmacological studies revealed that the sulfonamide analogues have excellent H4R affinity and behave as inverse agonists at the human H4R. In vivo evaluation of the potent 2-(6-chloro-2-(4-methylpiperazin-1-yl)quinazoline4-amino)-N- phenylethanesulfonamide (54) (pki = 8.31 ± 0.10) revealed it to have anti-inflammatory activity in an animal model of acute inflammation.
ADENOSINE A2A RECEPTOR ANTAGONISTS
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Page/Page column 12, (2008/12/04)
Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein: X1 and X2 are 1-3 substituents independently selected from the group consisting of H, alkyl, halo, —CF3, —OCF3, alkoxy, —OH and —CN;n is 0, 1 or 2; andR and R1 are H or alkyl; also disclosed is the use of the compounds in the treatment of CNS diseases such as Parkinson's disease, alone or in combination with other agents for treating CNS diseases, pharmaceutical compositions comprising them and kits comprising the components of the combinations.
