314-46-5 Usage
Description
2-Amino-6-(trifluoromethyl)benzoic acid is an organic compound characterized by the presence of an amino group at the 2nd position and a trifluoromethyl group at the 6th position on a benzene ring. It possesses a carboxylic acid functional group, which endows it with acidic properties and the ability to form salts and esters. 2-Amino-6-(trifluoromethyl)benzoic acid is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
2-Amino-6-(trifluoromethyl)benzoic acid is used as a key intermediate in the synthesis of heterocyclyl substituted acetamides. These acetamides serve as inhibitors of human immunodeficiency virus (HIV) replication, playing a crucial role in the development of antiretroviral drugs for the treatment of HIV/AIDS. The trifluoromethyl group in this compound enhances the lipophilicity and metabolic stability of the resulting drugs, thereby improving their pharmacokinetic properties and therapeutic efficacy.
In addition to its application in HIV treatment, 2-Amino-6-(trifluoromethyl)benzoic acid can also be utilized in the development of other therapeutic agents targeting different diseases and conditions. Its unique structural features and reactivity make it a valuable building block for the design and synthesis of novel pharmaceuticals with improved potency, selectivity, and safety profiles.
Used in Agrochemical Industry:
2-Amino-6-(trifluoromethyl)benzoic acid can also find applications in the agrochemical industry as a precursor for the synthesis of various agrochemicals, such as herbicides, insecticides, and fungicides. The trifluoromethyl group imparts increased lipophilicity and metabolic stability to the resulting agrochemicals, which can lead to enhanced performance and reduced environmental impact.
Furthermore, the versatility of 2-Amino-6-(trifluoromethyl)benzoic acid allows it to be used in the development of new agrochemicals with novel modes of action, improved selectivity, and reduced resistance potential. This can contribute to more sustainable and effective crop protection strategies, ultimately benefiting agriculture and food security.
Check Digit Verification of cas no
The CAS Registry Mumber 314-46-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 314-46:
(5*3)+(4*1)+(3*4)+(2*4)+(1*6)=45
45 % 10 = 5
So 314-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F3NO2/c9-8(10,11)4-2-1-3-5(12)6(4)7(13)14/h1-3H,12H2,(H,13,14)
314-46-5Relevant articles and documents
METHOD FOR PRODUCING 4(3H)-QUINAZOLINONE DERIVATIVE
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Page/Page column 12-13, (2008/06/13)
Disclosed is a method for producing 2-methyl-3-{4- [3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazine-4-one with 4-[3-(1-pirrolidinyl)propoxy]aniline or an acid addition salt thereof, or 4-(1-cyclobutyl-4-piperidinyl)oxyaniline or an acid addition salt thereof in the presence of an acetic acid catalyst.
Anthranilic acid derivatives
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, (2008/06/13)
Agents for lowering glucose levels in blood having the formula: STR1 wherein Ro is bromo, chloro, fluoro, nitro or trifluoromethyl, R is hydrogen, C1-6 alkyl or C2-18 alkanoyl, and R1 is hydrogen or C1-12 alkyl, and the non-toxic, pharmaceutically acceptable salts thereof.
