13466-29-0

Basic information

• Product Name: N-(benzylideneamino)methanamine
• Synonyms: N-(benzylideneamino)methanamine;Benzaldehyde methyl hydrazone;N'-Methylbenzaldehyde hydrazone
• CAS NO: 13466-29-0
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.17800
• Mol File: 13466-29-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 229.2°Cat760mmHg
• Flash Point: 92.4°C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 0.0706mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: N-(benzylideneamino)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzylideneamino)methanamine(13466-29-0)
• EPA Substance Registry System: N-(benzylideneamino)methanamine(13466-29-0)

Safety Data

• Hazardous Substances Data: 13466-29-0(Hazardous Substances Data)

Usage

General Description

N-(benzylideneamino)methanamine is a chemical compound with the molecular formula C8H10N2. It is an organic compound that contains both an aromatic benzene ring and an amino group. N-(benzylideneamino)methanamine can be used as a ligand in coordination chemistry, as well as in organic synthesis for the preparation of various types of molecules. It is also known to have biological activity and has been studied for its potential use in pharmaceutical applications. N-(benzylideneamino)methanamine is a versatile compound that has applications in a variety of fields, from chemical research to drug discovery.

InChI:InChI=1/C8H10N2/c1-9-10-7-8-5-3-2-4-6-8/h2-7,9H,1H3/b10-7+

Upstream product

• 100-52-7 benzaldehyde 
• 60-34-4 methylhydrazine 
• 622-29-7 N-Benzylidenemethylamine 
• 7732-18-5 water 
• 120-46-7 1,3-diphenylpropanedione 
• 93-91-4 1-phenylbutan-1,3-dione 
• 1202447-73-1 ethyl 2-benzoyl-3-oxo-2,3-dihydrobenzo[b]selenophene-2-carboxylate 
• 1202447-74-2 2,2-dibenzoylbenzo[b]selenophen-3(2H)-one 
• 1202447-75-3 2-benzoyl-2-nitrobenzo[b]selenophen-3(2H)-one 
• 1202447-76-4 diethyl 2-benzoyl-3-oxo-2,3-dihydrobenzo[b]selenophen-2-ylphosphonate 
• 102-96-5 (2-nitroethenyl)benzene 
• 932-90-1 Benzaldoxime 

Downstream Products

• 21303-67-3 3-(benzylidene-methyl-hydrazino)-2-cyano-acrylic acid ethyl ester 
• 5757-48-2 3-methyl-5-phenyl-[1,3,4]thiadiazolidine-2-thione 
• 33830-53-4 3,3,3-Trifluoro-2-trifluoromethyl-thiopropionic acid N-methyl-N'-[1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 10309-79-2 1-benzyl-2-methylhydrazine 
• 21907-04-0 N-Chloracetyl-N-methyl-N'-benzylidenhydrazin 
• 39182-12-2 (E)-3-{N-Methyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazino}-acrylic acid methyl ester 
• 13915-68-9 benzaldehyde 2-chloroformyl-2-methylhydrazone 
• 65889-71-6 3-(N²-benzylidene-N¹-methylhydrazino)-2-cyano-3-methylthioacrylonitrile 
• 35228-99-0 3,5-diphenyl-1-methyl-4-pyrazolol 
• 102276-32-4 N,1-Dimethyl-2-(phenylmethylen)-hydrazinsulfonamid 
• 125299-82-3 1-methyl-5-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)-3-phenylpyrazole 
• 95642-85-6 C₁₀H₁₃N₃ 
• 143780-55-6 C₁₂H₁₇N₃ 
• 95642-87-8 Benzoic Acid 1-Benzylidene-2-methylhydrazidoimine 

Relevant articles and documents

Insertion and fragmentation of 2-ferrocenylmethylidene-1, 3-diketones upon their reactions with N-methylhydrazine

(Chemical Equation Presented) Reactions of 2-ferrocenylmethylidene-1,3- diketones (1a-c) with methylhydrazine afford mainly insertion products (～40-58%), viz., 1-(N′-acyl-N′-methylhydrazino)-1-ferrocenyl-2- acylethanes (7a-d), together with lesser amounts

One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines

A scalable, one-pot, enantioselective catalytic synthesis of 2-pyrazolines from beta-substituted enones and hydrazines is described. Pivoting on a two-stage catalytic Michael addition/condensation strategy, the use of an aldehyde to generate a suitable hydrazone derivative of the hydrazine was found to be key for curtailing background reactivity and tuning the catalyst-controlled enantioselectivity. The new synthetic method is easy to perform, uses a new and readily prepared cinchona-derived bifunctional catalyst, is broad in scope, and tolerates a range of functionalities with high enantioselectivity (up to >99:1 e.r.). The significant scalability of this methodology was demonstrated with the synthesis of more than 80 grams of a pyrazoline product with 89 % catalyst recovery.

SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)

Preparation of 5-Aryl-2-Alkyltetrazoles with Aromatic Aldehydes, Alkylhydrazine, Di-tert-butyl Azodicarboxylate, and [Bis(trifluoroacetoxy)iodo]benzene

A variety of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles were directly prepared in good to moderate yields by the reaction of aromatic aldehydes with methylhydrazine and benzylhydrazine, followed by treatment with di-tert-butyl azodicarboxylate and [bis(trifluoroacetoxy)iodo]benzene in a mixture of dichloromethane and 2,2,2-trifluoroethanol at room temperature. The present method is a novel one-pot preparation of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles through a [2N + 2N] combination under transition metal-free and mild conditions.