622-29-7Relevant articles and documents
Luminescent monocyclometalated cationic gold(iii) complexes: Synthesis, photophysical characterization and catalytic investigations
Zehnder, Thomas N.,Blacque, Olivier,Venkatesan, Koushik
, p. 11959 - 11972 (2014)
Stable, luminescent, and cationic monocyclometalated gold(iii) monoaryl complexes of the type [(ppy)Au(FMes)(L)]+[OTf]- [L = 4-phenylpyridine (3), quinoline (4), 4-fluoroaniline (5), P(OMe)3 (6), PPh3 (7)], bearing different ancillary ligands, synthesized starting from the precursor complex [(ppy)Au(FMes)(OH2)] +[OTf]- (2) are reported. The preliminary assignment of the structure of the complexes by various nuclear magnetic resonance spectroscopy techniques and elemental analysis has been further corroborated by single-crystal X-ray diffraction studies. The complexes exhibit room temperature phosphorescence in solution, in neat solids and in doped PMMA films. Detailed photophysical investigations of the complexes in solution, in neat solids and in PMMA films revealed the successful tuning of the emission quantum yield ( p) based on the electronic properties of the ancillary ligands. The catalytic photo-oxidation of benzylic amines to their corresponding imines using molecular oxygen as the oxidant was successfully achieved in the presence of the luminescent Au(iii) complexes. It is also established that the photocatalytic performance was strongly governed by the electronic properties of the ancillary ligands on the photosensitizer as well as by the steric bulk of the substrates. This journal is the Partner Organisations 2014.
Monoamine Oxidase-Catalyzed Amine Oxidation in Organic Solvents
Woo, Jonathan C. G.,Wang, Xueqing,Silverman, Richard B.
, p. 6235 - 6236 (1995)
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Discovery of tert-amine-based RORγt agonists
Qiu, Ruomeng,Yu, Mingcheng,Gong, Juwen,Tian, Jinlong,Huang, Yafei,Wang, Yonghui,Xie, Qiong
, (2021/07/26)
The nuclear receptor retinoic acid receptor-related orphan receptor gamma-t (RORγt) is a transcription factor regulating Th17 cell differentiation and proliferation from naive CD4+ T cells. Since Th17 cells have demonstrated the antitumor efficacy by eliciting remarkable activation of CD8+ T cells, RORγt agonists could be applied as potential small molecule therapeutics for cancer immunotherapy. Based on the previously reported RORγt agonist 1 and its resolved co-crystal structure, a series of new tertiary amines were designed, synthesized and biologically evaluated, yielding optimal moieties with improved chemical properties and biological responses. The combination of these optimal moieties resulted in identification of novel RORγt agonists such as 8b with further elevated RORγt agonism responses at a target-based level as well as in cell-based assays, which provided some structural knowledge for further optimization of RORγt agonists as small molecule therapeutics for cancer immunotherapy.
Photocatalytic selective aerobic oxidation of amines to nitriles over Ru/γ-Al2O3: The role of the support surface and the strong imine intermediate adsorption
Zhu, Pengqi,Zhang, Jin,Wang, Jie,Kong, Peng,Wang, Yunwei,Zheng, Zhanfeng
, p. 440 - 449 (2020/02/04)
Hydroxyl coordinated ruthenium dispersed on the surface of γ-Al2O3 can be applied to the selective oxidation of amines with light irradiation and an atmospheric pressure of O2 at room temperature. Sunlight is also an effective light source for the selective aerobic oxidation of primary amines to corresponding nitriles. The high photocatalytic activity and selectivity over Ru/γ-Al2O3 originate from the adsorption of amines and imine intermediates on the abundant surface OH groups of the photocatalyst and further formation of Ru-amide species by ligand exchange of adsorbed amines and imine intermediates with adjacent exposed active Ru sites. Light is introduced to the system successfully via the formation of Ru-amide species, which are used as the light absorption sites of the photocatalytic selective oxidation of amines. Primary amines are directly converted to corresponding nitriles via a two-step oxidative dehydrogenation process.
