134700-82-6

Basic information

• Product Name: 2-acetyl-5-methoxyphenyl 4-methoxybenzoate
• Synonyms: 2-acetyl-5-methoxyphenyl 4-methoxybenzoate
• CAS NO: 134700-82-6
• Molecular Weight: 300.311
• Mol File: 134700-82-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-acetyl-5-methoxyphenyl 4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-5-methoxyphenyl 4-methoxybenzoate(134700-82-6)
• EPA Substance Registry System: 2-acetyl-5-methoxyphenyl 4-methoxybenzoate(134700-82-6)

Safety Data

• Hazardous Substances Data: 134700-82-6(Hazardous Substances Data)

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 20979-50-4 4,7-dimethoxyflavone 
• 134701-10-3 4-(2-Hydroxy-4-methoxy-phenyl)-6-(4-methoxy-phenyl)-pyrimidin-2-ol 
• 56588-15-9 6-Methoxy-2-<4-methoxy-benzoyl>-cumaran-3-on 
• 75335-16-9 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione 

Relevant articles and documents

Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma

Background: Cancers of the lymphatic cells (lymphomas) account for approximately 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt’s lymphoma (BL). Objectives: The aims of the curent study were to synthesise a panel of nitrostyrene compounds and to evaluate their activity in Burkitt’s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesised using Henry Knoevenagel condensation reactions. Single crystal X-Ray analysis confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, respectively, in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt’s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt’s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy.

Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

Preparation and antibacterial activity of 2-hydroxy-4,6-diphenylpyrimidines

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