75335-16-9

Basic information

• Product Name: 1,3-Propanedione, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-
• CAS NO: 75335-16-9
• Molecular Formula: C17H16O5
• Molecular Weight: 300.311
• Mol File: 75335-16-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-(75335-16-9)
• EPA Substance Registry System: 1,3-Propanedione, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-(75335-16-9)

Safety Data

• Hazardous Substances Data: 75335-16-9(Hazardous Substances Data)

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 134700-82-6 2-acetyl-5-methoxyphenyl 4-methoxybenzoate 
• 794-94-5 p-Methoxybenzoic anhydride 

Downstream Products

• 1438433-43-2 1-(2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)butane-1,4-dione 
• 2196-14-7 7,4'-Dihydroxyflavon 
• 141214-05-3 2-methyl-1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)propane-1,3-dione 
• 134701-10-3 4-(2-Hydroxy-4-methoxy-phenyl)-6-(4-methoxy-phenyl)-pyrimidin-2-ol 
• 20979-50-4 4,7-dimethoxyflavone 

Relevant articles and documents

Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

One pot synthesis of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones by modified Baker-Venkataraman transformation using microwave irradiation

Reaction of 2-hydroxyacetophenones with aromatic acid anhydrides in the presence of anhydrous barium hydroxide in dimethyl sulfoxide using microwave irradiation gives 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones directly in a single pot reaction in high yields.

New synthesis of 1,3-diarylpropane-1,3-diones

1,3-Diarylpropane-1,3-diones have been synthesized by (i) UV irradiation and thermal rearrangement of o-aroyloxyacetophenones and (ii) microwave irradiation of aroyl chlorides and o-hydroyacetophenones.