134924-71-3

Basic information

• Product Name: trans-Hydroxy Praziquantel
• Synonyms: trans-Hydroxy Praziquantel;trans-1,2,3,6,7,11b-Hexahydro-2-[(4-hydroxycyclohexyl)carbonyl]- 4H-pyrazino[2,1-a]isoquinolin-4-one
• CAS NO: 134924-71-3
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.40546
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 134924-71-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 591.3°C at 760 mmHg
• Flash Point: 311.4°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 7.9E-15mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly)
• CAS DataBase Reference: trans-Hydroxy Praziquantel(CAS DataBase Reference)
• NIST Chemistry Reference: trans-Hydroxy Praziquantel(134924-71-3)
• EPA Substance Registry System: trans-Hydroxy Praziquantel(134924-71-3)

Safety Data

• Hazardous Substances Data: 134924-71-3(Hazardous Substances Data)

Usage

Description

Trans-Hydroxy Praziquantel, also known as the main trans-monohydroxylated metabolite of Praziquantel (P702095), is a white solid with significant pharmaceutical potential. It is derived from the metabolism of Praziquantel, a widely used antiparasitic drug. The presence of hydroxy groups in its chemical structure allows for interactions with various biological targets, making it a promising candidate for further research and development in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
Trans-Hydroxy Praziquantel is used as an active pharmaceutical ingredient for the development of new drugs targeting parasitic infections. Its hydroxy group enables it to interact with specific biological targets, potentially enhancing the efficacy of antiparasitic treatments.
Used in Research and Development:
In the field of pharmaceutical research and development, Trans-Hydroxy Praziquantel serves as a valuable compound for studying the mechanisms of action and potential applications of Praziquantel and its metabolites. This can lead to the discovery of new therapeutic approaches and the development of more effective antiparasitic drugs.
Used in Drug Delivery Systems:
Similar to Gallotannin, Trans-Hydroxy Praziquantel can be incorporated into novel drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the limitations of Trans-Hydroxy Praziquantel can be overcome, enhancing its overall effectiveness in treating parasitic infections.

InChI:InChI=1/C19H24N2O3/c22-15-7-5-14(6-8-15)19(24)20-11-17-16-4-2-1-3-13(16)9-10-21(17)18(23)12-20/h1-4,14-15,17,22H,5-12H2

Upstream product

• 57452-32-1 2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 914637-80-2 4-oxocyclohexane carboxylic acid chloride 

Relevant articles and documents

Synthesis and properties of cis- and trans-4-hydroxypraziquantel

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