57452-32-1

Basic information

• Product Name: rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one
• Synonyms: rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one;2-(4-oxocyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
• CAS NO: 57452-32-1
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.38958
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 57452-32-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Methanol
• CAS DataBase Reference: rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one(57452-32-1)
• EPA Substance Registry System: rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one(57452-32-1)

Safety Data

• Hazardous Substances Data: 57452-32-1(Hazardous Substances Data)

Usage

Description

rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one is a chemical compound that is structurally similar to praziquantel, an anthelmintic drug. It is characterized by its unique molecular structure, which includes a hexahydro-pyrazino-isoquinolinone core and a cyclohexylcarbonyl group. rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one has potential applications in the pharmaceutical industry due to its structural resemblance to praziquantel.

Uses

Used in Pharmaceutical Industry:
rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one is used as an anthelmintic agent for the treatment of flatworm infections. Its structural similarity to praziquantel suggests that it may be effective against various flatworm parasites, including schistosomes, tapeworms, and flukes. rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one may also be used in the development of new drugs for the treatment of parasitic infections, potentially offering alternative treatment options for patients.
Used in Research and Development:
In addition to its potential therapeutic applications, rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one may also be used in research and development for the study of flatworm biology and the development of new anthelmintic drugs. Its structural resemblance to praziquantel makes it a valuable tool for understanding the mechanisms of action of this class of drugs and for identifying new targets for drug development.
Used in Drug Delivery Systems:
Similar to gallotannin, rac-1,2,3,6,7,11b-Hexahydro-2-[(4-oxocyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one may also benefit from the development of novel drug delivery systems to enhance its efficacy and bioavailability. These systems could include organic and metallic nanoparticles, liposomes, or other advanced drug delivery technologies, which could improve the compound's delivery to target parasites and increase its therapeutic potential.

Upstream product

• 914637-80-2 4-oxocyclohexane carboxylic acid chloride 
• 61196-37-0 2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 55375-92-3 (R)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 
• 99746-73-3 (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 

Downstream Products

• 134924-73-5 (-)-2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 134924-69-9 (-)-2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 134924-72-4 (+)-2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 134924-70-2 (+)-2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 134924-71-3 2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 134924-68-8 2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 

Relevant articles and documents

Development of chiral praziquantel analogues as potential drug candidates with activity to juvenile Schistosoma japonicum

A series of chiral praziquantel analogues were synthesized and evaluated against Schistosoma japonicum both in vitro and in vivo. All compounds exhibited low to considerable good activity in vivo. Remarkably, worm reduction rate of R-3 was 60.0% at a sing

Synthesis and properties of cis- and trans-4-hydroxypraziquantel

-