1350839-76-7

Basic information

• Product Name: 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one
• CAS NO: 1350839-76-7
• Molecular Weight: 416.566
• Mol File: 1350839-76-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one(1350839-76-7)
• EPA Substance Registry System: 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one(1350839-76-7)

Safety Data

• Hazardous Substances Data: 1350839-76-7(Hazardous Substances Data)

Upstream product

• 5308-25-8 4-ethylpiperazine 
• 57999-71-0 α-Phenacyl-zimtsaeure-hydrazid 
• 4361-96-0 3-benzylidene-5-phenylfuran-2(3H)-one 
• 20153-14-4 4-benzyl-6-phenylpyridazin-3(2H)-one 
• 74571-65-6 1-(3-chloropropyl)-4-ethylpiperazine 

Relevant articles and documents

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.