4361-96-0

Basic information

• Product Name: 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one
• Synonyms: 3-Benzylidene-5-phenyl-2(3H)-furanone;3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one;3-Benzylidene-5-phenylfuran-2(3H)-one;5-Phenyl-3-(phenylmethylene)furan-2(3H)-one;5-Phenyl-3-benzylidenefuran-2(3H)-one;γ-Phenyl-α-(phenylmethylene)-Δβ,γ-butenolide;CinnaMic acid, a-(b-hydroxystyryl)-, g-lactone
• CAS NO: 4361-96-0
• Molecular Formula: C₁₇H₁₂O₂
• Molecular Weight: 248.276
• Mol File: 4361-96-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 472.5°Cat760mmHg
• Flash Point: 200.1°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 4.25E-09mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one(4361-96-0)
• EPA Substance Registry System: 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one(4361-96-0)

Safety Data

• Hazardous Substances Data: 4361-96-0(Hazardous Substances Data)

Usage

General Description

3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one is a chemical compound with a molecular formula C18H14O2. It is a yellow crystalline solid that is commonly used in the synthesis of various pharmaceuticals and other organic compounds. 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one has been studied for its potential antioxidant and antimicrobial properties, and it has also been investigated for its potential use in the development of new drugs. Additionally, 3-Benzylidene-5-phenyl-2,3-dihydrofuran-2-one has been found to exhibit anti-inflammatory and analgesic effects in some preclinical studies. Overall, this compound has shown promise in various research areas and is of interest to scientists and researchers in the fields of chemistry, pharmacology, and drug development.

InChI:InChI=1/C17H12O2/c18-17-15(11-13-7-3-1-4-8-13)12-16(19-17)14-9-5-2-6-10-14/h1-12H

Upstream product

• 57999-77-6 α-phenacylcinnamic acid 
• 158426-75-6 2-benzylidene-4-phenyl-but-3-enoic acid 
• 13304-18-2 2-benzoyl-3-phenyl-cyclopropanecarboxylic acid 
• 127157-60-2 2-benzyl-2-hydroxy-4-oxo-4-phenyl-butyric acid 
• 51615-57-7 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylic acid 
• 100-52-7 benzaldehyde 
• 2051-95-8 succinylbenzene 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 10035-10-6 hydrogen bromide 
• 904819-19-8 β-truxinamic acid 
• 7596-81-8 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylic acid dimethyl ester 

Downstream Products

• 102756-66-1 1-(2-phenacyl-3ξ-phenyl-acryloyl)-piperidine 
• 65155-72-8 2-phenacyl-3-phenyl-acrylic acid benzylamide 
• 57999-77-6 α-phenacylcinnamic acid 
• 17560-24-6 1-phenylnaphthalene-3-carboxylic acid 
• 5666-05-7 2-benzyl-4-phenylbutanoic acid 
• 51518-53-7 4-(2-benzylidene-4-oxo-4-phenyl-butyryl)-morpholine 
• 77811-59-7 4-Oxo-4-phenyl-2-[1-phenyl-meth-(Z)-ylidene]-butyric acid N'-phenyl-hydrazide 
• 77811-54-2 N-Methyl-4-oxo-4-phenyl-2-[1-phenyl-meth-(Z)-ylidene]-butyramide 
• 101536-89-4 5-Phenyl-3-[1-phenyl-meth-(E)-ylidene]-3H-furan-2-thione 
• 93328-60-0 4-(4-Chlor-phenyl)-2-naphthoesaeure 
• 77811-83-7 1-Methyl-5-phenyl-3-[1-phenyl-meth-(E)-ylidene]-1,3-dihydro-pyrrol-2-one 
• 77811-86-0 5-Phenyl-1-phenylamino-3-[1-phenyl-meth-(E)-ylidene]-1,3-dihydro-pyrrol-2-one 
• 20153-14-4 4-benzyl-6-phenylpyridazin-3(2H)-one 
• 1350839-76-7 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

A ligand-based approach was applied to screen in silico a library of commercially available compounds, with the aim to find novel inhibitors of the HCV replication starting from the study of the viral NS3 helicase. Six structures were selected for evaluat

Microwave assisted Perkin reaction for the synthesis of α-arylidine-γ-phenyl-Δ, β, γ-butenolides

Perkin condensation with subsequent intramolecular lactonisation as one pot synthesis of α-arylidine-γ-phenyl-Δ,β,γ- butenolides have been studied under microwave irradiation. The butenolides are cleaved to give keto acids, which are the precursors of pericarbonyl lactone lignans possessing variety of biological activities. Syntheses of butenolides have been carried out using pyridine as a catalyst under microwave conditions. The generality of this protocol has been demonstrated by synthesizing a variety of substituted butenolides in excellent yields, short reaction time and with good purity compared to those under classical thermal conditions. All the products have been characterized by their IR, 1H NMR and UV spectral values.

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.