5666-05-7

Basic information

• Product Name: Benzenebutanoic acid, a-(phenylmethyl)-
• Synonyms: 1.4-Diphenyl-butan-carbonsaeure-(2);2-Benzyl-4-phenyl-buttersaeure;2-Benzyl-4-phenyl-butyric acid;Benzyl-β-phenaethyl-essigsaeure;γ-Phenyl-α-benzyl-buttersaeure;α.δ-Diphenyl-butan-β-carbonsaeure
• CAS NO: 5666-05-7
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Mol File: 5666-05-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 54 - 55 °C
• Boiling Point: 198 °C(Press: 1 Torr)
• Density: 1.118±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenebutanoic acid, a-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, a-(phenylmethyl)-(5666-05-7)
• EPA Substance Registry System: Benzenebutanoic acid, a-(phenylmethyl)-(5666-05-7)

Safety Data

• Hazardous Substances Data: 5666-05-7(Hazardous Substances Data)

Upstream product

• 5669-19-2 2-Benzyl-2-propenoic acid 
• 401636-52-0 di-tert-butyl 4-benzyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 122-78-1 phenylacetaldehyde 
• 120790-93-4 dimethyl 2-(2-phenylethyl)propanedioate 
• 17376-04-4 2-phenethyl iodide 
• 1166181-96-9 methyl 2-benzyl-4-phenylbutanoate 
• 100-39-0 benzyl bromide 
• 6628-68-8 ethyl 2-(ethoxycarbonyl)-4-phenylbutanoate 
• 861330-04-3 diethyl 2-benzyl-2-phenethylmalonate 
• 857814-26-7 2-(α-bromo-benzyl)-4-phenyl-but-3-enoic acid methyl ester 
• 4361-96-0 3-benzylidene-5-phenylfuran-2(3H)-one 
• 501359-00-8 benzyl-phenethyl-malonic acid 
• 104905-00-2 gamma-oxo-α-(phenylmethyl)benzenebutanoic acid 
• 57999-77-6 α-phenacylcinnamic acid 

Downstream Products

• 1166182-26-8 (acetyloxy)methyl 2-benzyl-4-phenylbutanoate 
• 132797-26-3 2-benzyl-1-tetralone 

Relevant articles and documents

Substituted Hantzsch Esters as Versatile Radical Reservoirs in Photoredox Reactions

Substituted Hantzsch esters can act as radical reservoirs in photoredox reactions, steadily releasing a carbon radical and a hydrogen atom radical in the absence of an additional electron acceptor. We propose that radical release by substituted Hantzsch esters occurs via a mechanism involving an internal redox cycle. Cinnamidecinnamides, styrenes, α,β-unsaturated acids, and diarylethenes could be alkylated smoothly with these reagents. (Figure presented.).

NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS

Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: -(CH2)1-4-, (C2-C4)-alkenyl, (C2-C4)alkynyl, -S-(CH2)1-3-#, and -(CH2)1-3-O-#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: -(CH2)2-4-, -S-(CH2)1-3#, and -O-(CH2)1-3-#,; where in the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: -OR4. The compounds of formula (I) are useful in the treatment of cancer