135145-90-3 Usage
Description
2,5-Dichlorophenylboronic acid is an organic compound with the chemical formula C6H4Cl2BO2H. It is a white to off-white powder and is commonly used as a reactant in various chemical reactions and synthesis processes. Its chemical structure features a boronic acid group attached to a dichloro-substituted benzene ring, which allows it to participate in a range of chemical reactions.
Uses
1. Used in Pharmaceutical Industry:
2,5-Dichlorophenylboronic acid is used as a reactant for the synthesis of Dipeptidyl peptidase IV (DPP4) inhibitors, which are crucial in the treatment of type 2 diabetes. These inhibitors help regulate blood sugar levels by slowing down the degradation of certain hormones.
2. Used in Chemical Synthesis:
2,5-Dichlorophenylboronic acid is used as a reactant in various chemical reactions, such as:
a. Regioselective iodination using silver salts, which allows for the selective introduction of iodine atoms into specific positions on the molecule.
b. Pd-catalyzed Suzuki-Miyaura coupling, a widely used method for the formation of carbon-carbon bonds, particularly in the synthesis of complex organic molecules.
c. Rhodium(I)-catalyzed carbonylative cyclization of alkynes, a reaction that involves the formation of cyclic compounds with a carbonyl group.
d. Copper-catalyzed coupling reactions, which are employed in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 135145-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,1,4 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 135145-90:
(8*1)+(7*3)+(6*5)+(5*1)+(4*4)+(3*5)+(2*9)+(1*0)=113
113 % 10 = 3
So 135145-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BCl2O2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,10-11H
135145-90-3Relevant articles and documents
Pyrazine compounds
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, (2008/06/13)
A compound of formula (I) wherein R1is selected from the group consisting of phenyl substituted by one or more halogen atoms, naphthyl and naphthyl substituted by one or more halogen atoms; R2is selected from the group consisting of —NH2and —NHC(═O)Ra; R3is selected from the group consisting of —NRbRc, —NHC(═O)Raand hydrogen, R4is selected from the group consisting of hydrogen, -C1-4alkyl, -C1-4alkyl substituted by one or more halogen atoms, —CN, —CH2OH, —CH2ORdand —CH2S(O)xRd; wherein Rarepresents C1-4alkyl or C3-7cycloalkyl, and Rband Rc, which may be the same or different, are selected from hydrogen and C1-4alkyl, or together with the nitrogen atom to which they are attached, form a6-membered nitrogen containing heterocycle, which heterocycle can be further susbtituted with one or more C1-4alkyl; Rdis selected from C1-4alkyl or C1-4alkyl substituted by one or more halogen atoms; x is an integer zero, one or two; and pharmaceutically acceptable derivatives thereof; with the proviso that R1does not represent (a); when R2is —NH2, and both R3and R4are hydrogen.
