1435-50-3

Basic information

• Product Name: 2-Bromo-1,4-dichlorobenzene
• Synonyms: 2-BROMO-1,4-DICHLOROBENZENE;2,5-DICHLOROBROMOBENZENE;1-BROMO-2,5-DICHLOROBENZENE;Benzene, 1-bromo-2,5-dichloro-;2-Bromo-1,4-dichlorobenzene, 98+%;2,5-Dichlorophenyl bromide;1-Bromo-2,5-dichlorobenzene,99%;2-Bromo-1,4-dichloro
• CAS NO: 1435-50-3
• Molecular Formula: C₆H₃BrCl₂
• Molecular Weight: 225.9
• EINECS: 215-859-9
• Product Categories: Bromine Compounds;Chlorine Compounds
• Mol File: 1435-50-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 32-36 °C(lit.)
• Boiling Point: 118-120°C 20mm
• Flash Point: >230 °F
• Appearance: white to light yellow crystal powder
• Density: 1.6351 (rough estimate)
• Vapor Pressure: 0.0736mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: insoluble
• BRN: 1934815
• CAS DataBase Reference: 2-Bromo-1,4-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1,4-dichlorobenzene(1435-50-3)
• EPA Substance Registry System: 2-Bromo-1,4-dichlorobenzene(1435-50-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-36-28A
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1435-50-3(Hazardous Substances Data)

Usage

Description

2-Bromo-1,4-dichlorobenzene is an organic compound that exists as a white to light yellow crystal powder. It is characterized by the presence of a bromine atom and two chlorine atoms attached to a benzene ring.

Uses

Used in Pharmaceutical Industry:
2-Bromo-1,4-dichlorobenzene is used as a reactant for the synthesis of C-13 and C-14-labeled versions of the investigational proteasome inhibitor MLN9708. This application is significant as it aids in the development of new drugs and therapies for various medical conditions.

InChI:InChI=1/C6H3BrCl2/c7-5-3-4(8)1-2-6(5)9/h1-3H

Upstream product

• 95-82-9 2,5 dichloroaniline 
• 15470-55-0 2,5-dichlorobenzenediazonium 
• 1940-27-8 2,5-dichloro-4-bromo-aniline 
• 88-42-6 2,5-dichlorobenzenesulfonic acid 
• 873-38-1 4-chloro-2-bromoaniline 
• 106-46-7 para-dichlorobenzene 
• 22459-81-0 N-(4-bromo-3-chlorophenyl)acetamide 
• 199608-48-5 4-bromo-2,5-dichloroacetanilide 
• 89-61-2 2,5-dichloronitrobenzene 
• 71-43-2 benzene 

Downstream Products

• 106-46-7 para-dichlorobenzene 
• 1984-58-3 2,5-dichloroanisole 
• 583-78-8 2,5-dichlorophenol 
• 68557-76-6 2-bromo-1,4-dichloro-3,5-dinitro-benzene 
• 170098-91-6 4-bromo-2,5-dichloronitrobenzene 
• 2051-61-8 m-chlorobiphenyl 
• 34883-39-1 2,5-dichlorobiphenyl 
• 1019-90-5 5-chloro-2-phenyl-1,3-benzoxazole 
• 16606-02-3 2,4',5-Trichlorobiphenyl 
• 849766-51-4 4-(2,5-dichloro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 286469-96-3 4-(2-chloro-5-chlorobenzyl)piperidine 
• 135145-90-3 2,5-dichlorobenzeneboronic acid 
• 1172638-96-8 2-(2,5-dichloro-phenyl)-cycloheptanol 
• 100191-22-8 2,3-dibromo-1,4-dichlorobenzene 

Relevant articles and documents

A method for the synthesis of 2, 5 - dichlorophenol (by machine translation)

The invention relates to a 2, 5?Dichiorophenol synthetic method, which belongs to the technical field of the synthesis of the key intermediate chamber. The invention is composed of a pure chlorization generated 1, 2, 4?Trichlorobenzene and santochlor is easy to separate, thereby avoiding the difficulties caused by the separating of the high production cost and low production efficiency; because the 1, 2, 4?Trichlorobenzene and to two chiorophenoxy can be obtained respectively 2, 5?Dichiorophenol, utilization rate of raw materials is high, thereby avoiding the waste of the by-product, so that the production cost is greatly reduced. In addition, the two paradichlorbenzene through two different method to obtain 2, 5?Dichiorophenol. The synthesis technique of this invention is simple, the production cost is low, the utilization rate of raw materials is high, and the craft there are few by-products, less generation of three wastes, is more suitable for large-scale industrial production. (by machine translation)

Bromination of aromatic compounds using an Fe2O 3/zeolite catalyst

The catalytic bromination of non-activated aromatic compounds has been achieved using an Fe2O3/zeolite catalyst system. FeBr 3 was identified as the catalytic species, formed in situ from HBr and Fe2O3. The catalyst was easy-to-handle and cost effective and could also be recycled. The reaction system was also amenable to the one-pot sequential bromination/C-C bond formation of benzene.

Use of Potassium Bromate: Bromination of Halobenzenes and Halobenzoic Acids

Syntheses of bromo compounds by the bromination of halobenzenes and halobenzoic acids using potassium bromate under acidic condition have been discussed.