1352417-08-3

Basic information

• Product Name: (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide
• Synonyms: (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide
• CAS NO: 1352417-08-3
• Molecular Weight: 447.392
• Mol File: 1352417-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide(1352417-08-3)
• EPA Substance Registry System: (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide(1352417-08-3)

Safety Data

• Hazardous Substances Data: 1352417-08-3(Hazardous Substances Data)

Upstream product

• 1352420-03-1 C₁₄H₁₃BrF₄N₂O 
• 1352420-02-0 C₁₄H₁₂BrF₄NOS 
• 1352420-01-9 C₁₄H₁₂BrF₄NO₂ 
• 1352420-00-8 C₁₄H₁₃BrF₃NO₃ 
• 1352419-99-8 C₁₃H₁₂BrNO₃ 
• 1352419-98-7 C₁₃H₁₃BrClNO₃ 
• 1352419-97-6 C₁₁H₁₂BrNO₂*ClH 
• 1352419-96-5 C₁₅H₂₀BrNO₃S 
• 62123-80-2 ethyl 2-(3-bromo-phenyl)-2-oxo-acetate 
• 1352420-05-3 C₁₄H₁₅F₄N₃O 
• 53234-55-2 5-cyano-pyridine-2-carboxylic acid 

Relevant articles and documents

5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta- amyloid.