1352420-05-3

Basic information

• Product Name: C₁₄H₁₅F₄N₃O
• Synonyms: C₁₄H₁₅F₄N₃O
• CAS NO: 1352420-05-3
• Molecular Weight: 317.286
• Mol File: 1352420-05-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₅F₄N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₅F₄N₃O(1352420-05-3)
• EPA Substance Registry System: C₁₄H₁₅F₄N₃O(1352420-05-3)

Safety Data

• Hazardous Substances Data: 1352420-05-3(Hazardous Substances Data)

Upstream product

• 1352419-95-4 C₁₈H₂₆BrNO₃S 
• 1352419-94-3 C₁₅H₂₀BrNO₃S 
• 1352420-03-1 C₁₄H₁₃BrF₄N₂O 
• 1352419-97-6 C₁₁H₁₂BrNO₂*ClH 
• 1352419-96-5 C₁₅H₂₀BrNO₃S 
• 1336-21-6 ammonium hydroxide 

Downstream Products

• 1352417-08-3 (2S,3R)-N-{3-[5-amino-3-cyclopropyl-2-fluoro-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-cyanopyridine-2-carboxamide 
• 1443259-21-9 (5R,6S)-5-cyclopropyl-6-fluoro-5-{3-[(3-methoxypyridin-2-yl)amino]phenyl}-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine hydrochloride 

Relevant articles and documents

5-(3-AMINOPHENYL)-5-ALKYL-5,6-DIHYDRO-2H-[1,4]OXAZIN-3-AMINE DERIVATIVES

The present invention relates to novel 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2H-[1,4]oxazin-3-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also direct

5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta- amyloid.