1353891-52-7

Basic information

• Product Name: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate
• Synonyms: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate
• CAS NO: 1353891-52-7
• Molecular Weight: 411.285
• Mol File: 1353891-52-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate(1353891-52-7)
• EPA Substance Registry System: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate(1353891-52-7)

Safety Data

• Hazardous Substances Data: 1353891-52-7(Hazardous Substances Data)

Upstream product

• 3848-36-0 4-chlorobenzaldoxime 
• 29559-24-8 4-chlorophenylnitromethane 
• 779342-75-5 tert-butyl 4-chlorobenzylidenecarbamate 
• 774225-25-1 N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine 
• 4248-19-5 tert-butyl carbazate 
• 104-88-1 4-chlorobenzaldehyde 
• 622-95-7 4-chlorobenzyl bromide 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 548472-68-0 nutlin-3a 
• 1353891-88-9 tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate 
• 1353891-92-5 N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide 
• 1353891-90-3 tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate 
• 1353891-93-6 N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide 

Relevant articles and documents

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Br?nsted Acid-Base Catalyst with Recycle

A stereoselective aza-Henry reaction between an arylnitromethane and Boc-protected aryl aldimine using a homogeneous Br?nsted acid-base catalyst was translated from batch format to an automated intermittent-flow process. This work demonstrates the advanta

ARYL-SUBSTITUTED IMIDAZOLES AND METHODS OF MAKING AND USING SAME

The compounds of the invention are antagonists of MDM2 and/or MDMX, with excellent specificity for MDM2 and/or MDMX over other proteins. Several analogs demonstrate selective binding affinity to MDMX over MDM2. The disclosed compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Efficient reactivation of p53 in cancer cells by a dual MdmX/Mdm2 inhibitor

The aberrant interaction between p53 and Mdm2/MdmX is an attractive target for cancer drug discovery because the overexpression of Mdm2 and/or MdmX ultimately impairs the function of p53 in approximately half of all human cancers. Recent studies have show