1354455-77-8

Basic information

• Product Name: 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
• Synonyms: 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
• CAS NO: 1354455-77-8
• Molecular Weight: 222.259
• Mol File: 1354455-77-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione(1354455-77-8)
• EPA Substance Registry System: 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione(1354455-77-8)

Safety Data

• Hazardous Substances Data: 1354455-77-8(Hazardous Substances Data)

Upstream product

• 614-45-9 tert-Butyl peroxybenzoate 
• 114433-94-2 1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione 
• 74-88-4 methyl iodide 

Downstream Products

• 1207460-34-1 4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine 
• 147118-36-3 N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide 
• 147118-37-4 N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 
• 799842-07-2 N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 

Relevant articles and documents

Concise and highly efficient approach to three key pyrimidine precursors for rosuvastatin synthesis

We report the synthesis of 5-formyl-, 5-(hydroxymethyl)-, and 5-(bromomethyl) substituted N-[4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N- methylmethanesulfonamide. The presented synthetic approach is based on highly efficient three step preparation of functionalized 5-methylpyrimidine. The methyl group is selectively brominated by NBS with irradiation into the bromomethyl derivative, which is then transformed into the hydroxymethyl or formyl groups in nearly quantitative yields. This approach is superior to the existing methodologies for the preparation of the key pyrimidine precursors used in the synthesis of rosuvastatin since no metal catalysis and no cryogenic reaction conditions are involved.

Method for preparing 2-methyl-1,3-dicarbonyl derivative

The invention discloses a method for preparing a 2-methyl-1,3-dicarbonyl derivative. A 1,3-dicarbonyl derivative serves as an initiator, raw materials are easy to obtain, and a great variety of raw materials are available. The product obtained through the method has high type diversity and can be used directly or used for other further reactions. Besides, only organic peroxides and a catalytic amount of inorganic copper salt are used, so that cost is low. According to the method, a reaction is conducted in air, reaction conditions are mild, pollution is small, reaction time is short, the yield of the target product is high, reaction operation and aftertreatment are easy, and the method is suitable for industrial production.

Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.