456-03-1

Basic information

• Product Name: 1-Propanone,1-(4-fluorophenyl)-
• Synonyms: Propiophenone,4'-fluoro- (6CI,7CI,8CI);1-(4-Fluorophenyl)propan-1-one;4-Fluorophenylpropanone;4-Fluoropropiophenone;Ethyl4-fluorophenyl ketone;p-Fluoropropiophenone;NSC 63354
• CAS NO: 456-03-1
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• EINECS: 207-255-9
• Product Categories: C9;Carbonyl Compounds;Ketones;Fluorine Compounds;Aromatic Ketones (substituted);ketone;Fluorobenzene;Acetophenone Series;Adehydes, Acetals & Ketones
• Mol File: 456-03-1.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 215.9 °C at 760 mmHg
• Flash Point: 82.6 °C
• Appearance: Clear yellow liquid after melting
• Density: 1.074 g/cm³
• Refractive Index: n20/D 1.5059(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 1210310
• CAS DataBase Reference: 1-Propanone,1-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone,1-(4-fluorophenyl)-(456-03-1)
• EPA Substance Registry System: 1-Propanone,1-(4-fluorophenyl)-(456-03-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-39-37/39
• RIDADR: 2735
• WGK Germany: 2
• Hazardous Substances Data: 456-03-1(Hazardous Substances Data)

Usage

Description

1-Propanone,1-(4-fluorophenyl)-, also known as 4'-Fluoropropiophenone, is an organic compound with the molecular formula C9H9FO. It is a clear yellow liquid after melting and is characterized by its unique chemical properties.

Uses

1. Used in Pharmaceutical Industry:
1-Propanone,1-(4-fluorophenyl)is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be incorporated into complex molecular structures.
2. Used in Chemical Synthesis:
1-Propanone,1-(4-fluorophenyl)is used as a key component in the preparation of specific chemical compounds, such as 2-(4-fluorophenyl)-3-methylquinoxaline, due to its reactive nature and compatibility with other chemical groups.
3. Used in Research and Development:
1-Propanone,1-(4-fluorophenyl)serves as a valuable compound in research and development for its potential applications in various fields, including material science, pharmaceuticals, and chemical engineering, as it can be further modified and studied for new uses and properties.

Upstream product

• 462-06-6 fluorobenzene 
• 79-03-8 propionyl chloride 
• 701-47-3 1-(4-fluorophenyl)propanol 
• 5724-03-8 1-(4-fluorophenyl)allyl alcohol 
• 104863-65-2 N-methyl-N-methoxypropionamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 459-57-4 4-fluorobenzaldehyde 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 100-52-7 benzaldehyde 
• 1354455-77-8 1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione 
• 114433-94-2 1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione 
• 74-96-4 ethyl bromide 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 345-94-8 2-bromo-1-(4-fluorophenyl)propan-1-one 
• 405-64-1 4-fluoro-n-propilbenzene 
• 394-06-9 2-(4-fluoro-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 390-34-1 6-bromo-2-(4-fluorophenyl)-3-methylquinoline-4-carboxylic acid 
• 345-06-2 2-(4-fluorophenyl)-3-methyl-1H-indole 
• 1765-18-0 (4-fluoro-phenyl)-[4-(4-fluoro-phenyl)-5-methyl-thiazol-2-yl]-amine 
• 701-47-3 1-(4-fluorophenyl)propanol 
• 2928-00-9 2-amino-4-(4’-fluorophenyl)-5-methyl-1,3-thiazole 
• 81112-09-6 2-chloro-1-(4-fluorophenyl)propan-1-one 
• 50415-71-9 methyl 2-(4-fluorophenyl)propanoate 
• 41159-15-3 2-Ethyl-2-(4-fluoro-phenyl)-[1,3]dithiolane 
• 85932-49-6 methyl 4-methyl-5-oxo-5(4' fluoro)-phenyl pentanoate 
• 26393-91-9 1-(4-fluorophenyl)-2-methylpropan-1-one 
• 79341-99-4 1-Fluoro-4-((E)-1-methoxy-propenyl)-benzene 

Relevant articles and documents

Photoredox/nickel-catalyzed hydroacylation of ethylene with aromatic acids

We report a general, practical and scalable hydroacylation reaction of ethylene with aromatic carboxylic acids with the synergistic combination of nickel and photoredox catalysis. Under ambient temperature and pressure, feedstock chemicals such as ethylene can be converted into high-value-added aromatic ketones in moderate to good yields (up to 92%) with reaction time of 2-6 hours.

Method for preparing alpha-alkyl substituted ketone compound

The invention relates to a method for preparing an alpha-alkyl substituted ketone compound, which comprises the following steps: preparing a primary alcohol compound and a secondary alcohol compound as raw materials, adding alkali; with a cyclic iridium complex as a catalyst and water as a reaction medium, heating and stirring the mixture and reacting for 10 to 24 hours under the protection of inert gas, and cooling a reaction product to room temperature after the reaction is finished; carrying out reduced pressure distillation and concentration to obtain a crude product, and carrying out column chromatography purification to obtain a series of alpha alkyl substituted ketone compounds. The method is simple to operate, available in raw materials, low in price, high in reaction efficiency and selectivity, good in adaptability to various functional groups and wide in substrate universality; since water is used as a reaction medium to meet the green and environment-friendly requirements, the method is environmentally friendly and is carried out at gram level, so that the potential of industrially synthesizing the alpha alkyl substituted ketone compound is achieved; therefore, The method has expanded application in the fields of medicines, organic synthesis and the like.

KOtBu-Mediated Domino Isomerization and Functionalization of Aromatic Allylic Alcohols

Transition-metal- as well as ligand-free base-mediated domino isomerization and alkylation of allylic alcohols is presented. This protocol features the conversion of simple allylic alcohols into the corresponding ketones through isomerization in the presence of a simple base. Significantly, these in situ generated ketones subsequently undergo alkylation with styrenes as electrophiles, in a domino one-pot fashion, as an atom- and step-economical chemical process.