135616-24-9Relevant articles and documents
Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
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Page/Page column 39-40, (2009/04/24)
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
Regioselective Conversion of Cycloalkanones to Vinyl Bromide with 1,2-Functionality Transposition. A General Strategem
Paquette, Leo A.,Dahnke, Karl,Doyon, Julien,He, Wei,Wyant, Kenetha,Friedrich, Dirk
, p. 6199 - 6205 (2007/10/02)
Cyclic β-keto esters, available by regioselective acylation of cycloalkanone enolates, are rapidly transformed to α,β-unsaturated acids.This functionality transposition allows the derived 3-hydroxy-4-methylthiazole-2-(3H)-thione derivatives to serve as precursors to synthetically useful vinyl bromides.The process involves heating the hydroxamate ester with AIBN in bromotrichloromethane solution.Alkylative and ring contractive variants of the methodology are highlighted.The short sequence makes available precursors to vinyl anions that are not otherwise conveniently accessible.