135634-18-3 Usage
Description
2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride is a chemical compound with a complex structure, characterized by the presence of a difluorophenyl group and a 4-piperidinylmethanone oxime moiety. It is a white to off-white crystalline solid and is soluble in water. 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride has been identified for its potential applications in various fields, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride is used as an intermediate in the synthesis of Iloperidone, an atypical antipsychotic drug. It is utilized for its ability to modulate dopamine and serotonin receptors, which contributes to the drug's efficacy in treating schizophrenia and other psychotic disorders.
Used in Preparation of Amine Derivatives:
2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride is also used in the preparation of amine derivatives, which are known as potassium channel blockers. These derivatives have potential applications in the treatment and prevention of autoimmune and inflammatory diseases. The compound's unique structure allows for the development of targeted therapies that can help manage these conditions more effectively.
Check Digit Verification of cas no
The CAS Registry Mumber 135634-18-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,6,3 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 135634-18:
(8*1)+(7*3)+(6*5)+(5*6)+(4*3)+(3*4)+(2*1)+(1*8)=123
123 % 10 = 3
So 135634-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H14F2N2O.ClH/c13-9-1-2-10(11(14)7-9)12(16-17)8-3-5-15-6-4-8;/h1-2,7-8,15,17H,3-6H2;1H/b16-12+;
135634-18-3Relevant articles and documents
Preparation method of iloperidone intermediate
-
Paragraph 0039; 0040, (2017/07/19)
The invention relates to a preparation method of an iloperidone intermediate. The preparation method comprises the following steps of (1) adding potassium hydroxide into methyl alcohol, and adding (2,4-difluorophenyl)-(4-piperidyl)ketoxime hydrochloride; (2) heating, and reacting for 2 to 3h at the controlled temperature of 50 to 60 DEG C; (3) cooling to room temperature, adding anhydrous MgSO4, stirring for 0.8 to 1.2h, sucking and filtering, and performing vacuum concentration on filtrate; (4) adding acetone, stirring for 0.4 to 0.6h at the room temperature, filtering, dripping a saturated HCl methyl alcohol solution while stirring the filtrate, so as to adjust a pH (potential of hydrogen) value to 2-3, sucking and filtering, and drying, so as to obtain a white solid, wherein the water content of methyl alcohol is less than 0.5%.
ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA
-
, (2011/06/10)
The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.