1356998-79-2 Usage
Description
2-Cyclopropyl-4-(4-fluorophenyl)-3-methylquinoline is an organic compound characterized by its quinoline structure, which features a fused six-membered and five-membered nitrogen-containing rings. The presence of a cyclopropyl group at the 2nd position, a 4-fluorophenyl group at the 4th position, and a methyl group at the 3rd position provides this compound with unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-Cyclopropyl-4-(4-fluorophenyl)-3-methylquinoline is used as a key intermediate in the synthesis of statins, which are a class of drugs widely prescribed for the treatment of high cholesterol and cardiovascular diseases. Its role in the production process is crucial for the development of these life-saving medications.
In the synthesis of statins, 2-cyclopropyl-4-(4-fluorophenyl)-3-methylquinoline serves as a building block that can be further modified and functionalized to produce the final statin drug molecules. The compound's unique structure allows for the creation of a diverse range of statins with varying potencies and selectivities, making it an essential component in the pharmaceutical industry's efforts to combat heart disease and other cholesterol-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1356998-79-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,6,9,9 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1356998-79:
(9*1)+(8*3)+(7*5)+(6*6)+(5*9)+(4*9)+(3*8)+(2*7)+(1*9)=232
232 % 10 = 2
So 1356998-79-2 is a valid CAS Registry Number.
1356998-79-2Relevant articles and documents
The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin
Fabris, Jan,Casar, Zdenko,Smilovic, Ivanagazi
, p. 1700 - 1710 (2012/07/27)
A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between a lactonized statin side-chain precursor and the triphenylphosphonium bromide salt of the corresponding quinoline heterocyclic core. The necessary O-tert-butyl(dimethyl)silyl-protected pitavastatin lactone was obtained in 75% yield and high purity by simple crystallization from aqueous methanol. Subsequent deprotection, hydrolysis, and cation exchange in a one-pot operation provided pitavastatin calcium in 93% yield. Georg Thieme Verlag Stuttgart · New York.
Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
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Page/Page column 57, (2012/03/26)
The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
