957137-31-4

Basic information

• Product Name: tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide
• Synonyms: tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide
• CAS NO: 957137-31-4
• Molecular Weight: 558.557
• Mol File: 957137-31-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide(957137-31-4)
• EPA Substance Registry System: tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide(957137-31-4)

Safety Data

• Hazardous Substances Data: 957137-31-4(Hazardous Substances Data)

Upstream product

• 998-40-3 tributylphosphine 
• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 

Downstream Products

• 1356998-79-2 2-cyclopropyl-4-(4-fluorophenyl)-3-methylquinoline 
• 1391833-21-8 (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(Z)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one 
• 1391833-12-7 (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one 
• 148516-15-8 (6S)-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-5,6-dihydro-2H-pyran-2-one 

Relevant articles and documents

The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin

A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between a lactonized statin side-chain precursor and the triphenylphosphonium bromide salt of the corresponding quinoline heterocyclic core. The necessary O-tert-butyl(dimethyl)silyl-protected pitavastatin lactone was obtained in 75% yield and high purity by simple crystallization from aqueous methanol. Subsequent deprotection, hydrolysis, and cation exchange in a one-pot operation provided pitavastatin calcium in 93% yield. Georg Thieme Verlag Stuttgart · New York.