148516-15-8 Usage
Description
(6S)-6-(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl-5,6-dihydro-2H-pyran-2-one is a phenylquinoline derivative with a complex chemical structure. It is characterized by its unique arrangement of atoms and functional groups, which contribute to its specific properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(6S)-6-(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl-5,6-dihydro-2H-pyran-2-one is used as an impurity in the production of Pitavastatin, a competitive inhibitor of HMG-CoA reductase. This application is due to its structural similarity to the active compound, which may affect the overall efficacy and safety of the final product.
Used in Antilipemic Applications:
As a derivative of phenylquinoline, (6S)-6-(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl-5,6-dihydro-2H-pyran-2-one may have potential antilipemic properties, which could be beneficial in the development of treatments for dyslipidemia and related conditions. Its application in this area is based on its chemical structure and the possibility of modulating lipid metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 148516-15-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,5,1 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 148516-15:
(8*1)+(7*4)+(6*8)+(5*5)+(4*1)+(3*6)+(2*1)+(1*5)=138
138 % 10 = 8
So 148516-15-8 is a valid CAS Registry Number.
148516-15-8Relevant articles and documents
The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin
Fabris, Jan,Casar, Zdenko,Smilovic, Ivanagazi
, p. 1700 - 1710 (2012/07/27)
A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between a lactonized statin side-chain precursor and the triphenylphosphonium bromide salt of the corresponding quinoline heterocyclic core. The necessary O-tert-butyl(dimethyl)silyl-protected pitavastatin lactone was obtained in 75% yield and high purity by simple crystallization from aqueous methanol. Subsequent deprotection, hydrolysis, and cation exchange in a one-pot operation provided pitavastatin calcium in 93% yield. Georg Thieme Verlag Stuttgart · New York.
