1391833-12-7

Basic information

• Product Name: (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one
• Synonyms: (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one
• CAS NO: 1391833-12-7
• Molecular Weight: 517.716
• Mol File: 1391833-12-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one(1391833-12-7)
• EPA Substance Registry System: (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one(1391833-12-7)

Safety Data

• Hazardous Substances Data: 1391833-12-7(Hazardous Substances Data)

Upstream product

• 1234331-54-4 2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}sulfonyl)benzo[d]thiazole 
• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 
• 1391833-13-8 [2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl trifluoroacetate 
• 154057-58-6 <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyltriphenylphosphonium bromide 
• 154057-57-5 diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate 
• 146578-99-6 <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyl(diphenyl)phosphine oxide 
• 1391833-19-4 {[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}(triphenyl)phosphonium trifluoroacetate 
• 1391833-18-3 tricyclohexyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium trifluoroacetate 
• 1391833-16-1 tricyclohexyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide 
• 1391833-14-9 tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium trifluoroacetate 
• 957137-31-4 tributyl{[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonium bromide 
• 1068433-24-8 (4R,6S)-4-(tert-butyldimethylsilyloxy)-6-(dihydroxymethyl)tetrahydro-2H-pyran-2-one 

Downstream Products

• 574705-92-3 sodium (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate 
• 148516-15-8 (6S)-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-5,6-dihydro-2H-pyran-2-one 

Relevant articles and documents

Highly stereoselective formal synthesis of rosuvastatin and pitavastatin through Julia-Kocienski olefination using the lactonized statin side-chain precursor

An expedient and simple synthetic approach to pitava statin and rosuvastatin final intermediates is described. The presented approach consists of completely stereoselective Julia-Kocienski olefination step (E/Z up to 300:1) between lactonized statin side-chain precursor and sulfone derivative of the corresponding pyrimidine and quinoline heterocyclic cores. The desired O-TBS protected statin lactones were isolated in 66-71% yield and high >97% purity (HPLC). Georg Thieme Verlag Stuttgart. New York.