1357294-66-6

Basic information

• Product Name: 4,5-dimethoxy-N-n-butyl-2-{[3-((methylsulfonyl)amino)phenyl]carboxamido}benzamide
• Synonyms: 4,5-dimethoxy-N-n-butyl-2-{[3-((methylsulfonyl)amino)phenyl]carboxamido}benzamide
• CAS NO: 1357294-66-6
• Molecular Weight: 449.528
• Mol File: 1357294-66-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,5-dimethoxy-N-n-butyl-2-{[3-((methylsulfonyl)amino)phenyl]carboxamido}benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethoxy-N-n-butyl-2-{[3-((methylsulfonyl)amino)phenyl]carboxamido}benzamide(1357294-66-6)
• EPA Substance Registry System: 4,5-dimethoxy-N-n-butyl-2-{[3-((methylsulfonyl)amino)phenyl]carboxamido}benzamide(1357294-66-6)

Safety Data

• Hazardous Substances Data: 1357294-66-6(Hazardous Substances Data)

Upstream product

• 113283-05-9 N-n-butyl-4,5-dimethoxy-2-nitrobenzamide 
• 29568-78-3 4,5-dimethoxy-2-nitrobenzoyl chloride 
• 28547-13-9 3-(methanesulfonamido)benzoic acid 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 1016674-83-1 2-amino-N-n-butyl-4,5-dimethoxybenzamide 
• 184896-92-2 3-methanesulfonylamino-benzoyl chloride 

Downstream Products

• 1357294-91-7 N-[3-(6,7-dimethoxy-3-n-butyl-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]methanesulfonamide 

Relevant articles and documents

Cytotoxic potential of novel 6,7-dimethoxyquinazolines

Herein, we report the synthesis and cytotoxicity of a series of substituted 6,7-dimethoxyquinazoline derivatives. The cytotoxic activity of all synthesized compounds has been evaluated against HCT116p53+/+ and HCT116p53 -/- colon cancer cells and a HEY ovarian cancer cell line naturally resistant to cisplatin. Nine of the tested compounds showed significant cytotoxicity in all cell lines at 10 μM. The most promising derivative (7c) showed IC50values of 0.7 and 1.7 μM in the two colon cancer cell lines.