1360590-86-8

Basic information

• Product Name: C₁₇H₁₂F₄N₂O₂
• Synonyms: C₁₇H₁₂F₄N₂O₂
• CAS NO: 1360590-86-8
• Molecular Weight: 352.288
• Mol File: 1360590-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₂F₄N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₂F₄N₂O₂(1360590-86-8)
• EPA Substance Registry System: C₁₇H₁₂F₄N₂O₂(1360590-86-8)

Safety Data

• Hazardous Substances Data: 1360590-86-8(Hazardous Substances Data)

Upstream product

• 214288-07-0 1-(2-amino-5-fluorophenyl)-2,2,2-trifluoroethanone 
• 253668-35-8 N-[4-fluoro-2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide 
• 114995-47-0 N-(4-Fluorophenyl)-2,2-dimethylpropanamide 
• 371-40-4 4-fluoroaniline 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 1593480-23-9 ethyl 2-(6-fluoro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)buta-2,3-dienoate 
• 1593480-09-1 (E)-ethyl 2-(8-fluoro-5-(4-methoxybenzyl)-4-oxo-9b-(trifluoromethyl)-4,5-dihydro-1H-azeto[1,2-c]quinazolin-2(9bH)-ylidene)acetate 
• 1577989-31-1 (R)-phenyl-2-(6-fluoro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate 

Relevant articles and documents

Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F3C-containing polycyclic dihydroquinazolinones

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethylN-acyl ketimines. Using aCinchonaalkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20?:?1 dr, up to 99% ee).