136258-10-1

Basic information

• Product Name: 2',6'-dihydroxy-4'-methoxy-3'-tetrahydropyranylacetophenone
• CAS NO: 136258-10-1
• Molecular Weight: 266.294
• Mol File: 136258-10-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2',6'-dihydroxy-4'-methoxy-3'-tetrahydropyranylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',6'-dihydroxy-4'-methoxy-3'-tetrahydropyranylacetophenone(136258-10-1)
• EPA Substance Registry System: 2',6'-dihydroxy-4'-methoxy-3'-tetrahydropyranylacetophenone(136258-10-1)

Safety Data

• Hazardous Substances Data: 136258-10-1(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 7507-89-3 2,6-dihydroxy-4-methoxy-acetophenone 

Relevant articles and documents

Synthesis of 2'-hydroxychalcone epoxides

Various preparations of some 2'-tetrahydropyran-2-yloxychalcone epoxides and removal of their tetrahydropyranyl (THP) protective groups in slightly aqueous acidic dioxane are described. So synthesised were 2'-hydroxy-6'-isopropoxy- and 2'-hydroxy-6'-methoxychalcone epoxide, as well as the 2-CF3, 4-Cl and 4-NO2 analogues of the latter. 2',4'-dihydroxy-6'-methoxychalcone epoxide was similarly prepared. In some other 6'-methoxy cases protective group removal was accompanied by epoxide solvolysis and the corresponding α,β-dihydroxydihydrochalcone was the only isolable product [2-OMe, 4-OMe, 3,4,5-(OMe)3 cases] or a byproduct [4-Me case]. Similarly prepared by THP removal were 2'-hydroxy-4'-methoxychalcone epoxide and 2',4'-dihydroxychalcone epoxide, whereas an attempt to convert 2',6'-ditetrahydropyranyloxychalcone epoxide into 2',6'-dihydroxychalcone epoxide gave the product of cyclisation of the latter, 3,5-dihydroxyflavanone.