136262-53-8

Basic information

• Product Name: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile
• Synonyms: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile
• CAS NO: 136262-53-8
• Molecular Weight: 337.537
• Mol File: 136262-53-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile(136262-53-8)
• EPA Substance Registry System: (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile(136262-53-8)

Safety Data

• Hazardous Substances Data: 136262-53-8(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 136786-35-1 (2R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl p-toluenesulfonate 
• 186642-08-0 (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane 
• 95514-04-8 (S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol 
• 95514-03-7 (R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 123444-67-7 (R)-3-[(tert-butyl)diphenylsilyloxy]-1-iodo-2-methylpropane 
• 136292-93-8 Methanesulfonic acid (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester 

Downstream Products

• 887278-78-6 tert-butyl-((2S,6S)-2,6-dimethyltridecyloxy)-diphenyl silane 
• 123444-69-9 (2S)-tert-butyl(2-methylpent-4-ynyloxy)diphenylsilane 
• 123465-13-4 (E)-(3S,7S,8S)-2-Benzenesulfonyl-8,9-bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one 
• 123444-72-4 (E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one 
• 123444-73-5 (E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-((2S,3S,5R,6S)-3-hydroxy-6-methoxy-5-methyl-tetrahydro-pyran-2-yl)-3,5-dimethyl-non-5-en-1-one 
• 123444-74-6 (2R,3S,5R,6S)-2-((E)-(1S,3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-methoxy-3,5-dimethyl-non-5-enyl)-3,6-dimethoxy-5-methyl-tetrahydro-pyran 
• 123444-70-2 (E)-(2S,3S,7S)-1-Benzyloxy-3-benzyloxymethyl-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-4-en-2-ol 
• 123444-71-3 C₃₈H₄₄O₅S 
• 136262-69-6 tert-Butyl-[(E)-(2S,4S,5R,6S)-4,5-dimethoxy-2,6-dimethyl-8-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-non-7-enyloxy]-diphenyl-silane 
• 136374-56-6 tert-Butyl-[(E)-(2S,4S,5R,6R)-4,5-dimethoxy-2,6-dimethyl-8-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-non-7-enyloxy]-diphenyl-silane 
• 136262-73-2 (2S,3R,4S,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-3,4-dimethoxy-2,6-dimethyl-heptan-1-ol 

Relevant articles and documents

3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

Compounds of formula (I) wherein Het1, Het2, R1, R2 and R3 are as defined in the description. Medicaments.

Anti-AIDS agents 81. design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors

In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3′ dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3), was also employed to study the influence of the backbone and the C-3 modification toward the anti-HIV activity of this compound class. This study enabled us to better understand the structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design and synthesis of compound 12 (EC50: 0.0006 μM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor.

Synthesis of optically active diastereomers of a nonproteic neurotrophic mimetic

The four diastereomers 3, elongated analogues of perhydroretinol, are synthesized starting from both optically pure 3-bromo-2-methyl-1-propanol enantiomers. All exhibit neurotrophic activity on cultured neuronal cells derived from fetal rat cerebral hemispheres.