186642-08-0

Basic information

• Product Name: (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane
• Synonyms: (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane
• CAS NO: 186642-08-0
• Molecular Weight: 391.423
• Mol File: 186642-08-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane(186642-08-0)
• EPA Substance Registry System: (R)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2-methylpropane(186642-08-0)

Safety Data

• Hazardous Substances Data: 186642-08-0(Hazardous Substances Data)

Upstream product

• 93381-28-3 (R)-3-bromo-2-methyl-1-propanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 136262-53-8 (3S)-4-[(tert-butyldiphenylsilyl)oxy]-3-methylbutanenitrile 
• 186642-40-0 [(2S,6R)-8-Benzenesulfonyl-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octyloxy]-tert-butyl-diphenyl-silane 
• 186642-42-2 [(2S,6S)-8-Benzenesulfonyl-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octyloxy]-tert-butyl-diphenyl-silane 
• 186642-19-3 tert-Butyl-[(2S,6R)-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octyloxy]-diphenyl-silane 
• 186642-21-7 tert-Butyl-[(2S,6S)-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octyloxy]-diphenyl-silane 
• 186642-35-3 Methanesulfonic acid (2R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester 
• 186642-15-9 Methanesulfonic acid (2S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptyl ester 
• 186642-10-4 (E)-(2R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,6-dimethyl-hept-3-en-1-ol 
• 186642-12-6 (E)-(2S,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,6-dimethyl-hept-3-en-1-ol 
• 186642-16-0 ((2S,6R)-7-Bromo-2,6-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 186642-18-2 ((2S,6S)-7-Bromo-2,6-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 186642-13-7 (2R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptan-1-ol 
• 186642-14-8 (2S,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-2,6-dimethyl-heptan-1-ol 
• 123444-68-8 (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal 

Relevant articles and documents

Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives

3-O-3′(or 2′)-Methylsuccinyl-betulinic acid (MSB) derivatives were separated by using recycle HPLC. The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3′S-Methylsuccinyl-betulinic acid (3′S-MSB, 4) exhibited potent anti-HIV

Remote chiral communication in coadsorber-induced enantioselective 2D supramolecular assembly at a liquid/solid interface

Remote chiral communication in 2D supramolecular assembly at a liquid/solid interface was investigated at the molecular level. The stereochemical information in a chiral coadsorber was transmitted over a flexible spacer with a length of up to five methylene groups to a 2D supramolecular assembly of achiral building blocks with the cooperation of specific hydrogen bonding between the chiral coadsorber and achiral building blocks and the confinement effect during 2D crystallization. When the position of the stereogenic center was changed with respect to the stereocontrolling moiety, an odd-even effect was found. A stereogenic center closer to the stereocontrolling moiety transmitted the stereochemical information to the 2D supramolecular assembly more reliably. This result is beneficial not only for mechanistic understanding of chiral communication in 2D supramolecular assembly on surfaces but also for the rational design of homochiral supramolecular assemblies on surfaces.

Anti-AIDS agents 81. design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors

In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3′ dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3), was also employed to study the influence of the backbone and the C-3 modification toward the anti-HIV activity of this compound class. This study enabled us to better understand the structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design and synthesis of compound 12 (EC50: 0.0006 μM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor.