136312-66-8

Basic information

• Product Name: (2R,3R)-3-hydroxy-2-methyl-3-phenylpropionic acid benzyl ester
• Synonyms: (2R,3R)-3-hydroxy-2-methyl-3-phenylpropionic acid benzyl ester
• CAS NO: 136312-66-8
• Molecular Weight: 270.328
• Mol File: 136312-66-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R)-3-hydroxy-2-methyl-3-phenylpropionic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-3-hydroxy-2-methyl-3-phenylpropionic acid benzyl ester(136312-66-8)
• EPA Substance Registry System: (2R,3R)-3-hydroxy-2-methyl-3-phenylpropionic acid benzyl ester(136312-66-8)

Safety Data

• Hazardous Substances Data: 136312-66-8(Hazardous Substances Data)

Upstream product

• 129823-42-3 1-(Benzyloxy)-1-<(trimethylsilyl)oxy>prop-1-ene 
• 100-52-7 benzaldehyde 
• 129823-43-4 (Z)-((1-(benzyloxy)prop-1-en-1-yl)oxy)trimethylsilane 
• 189098-09-7 (2S)ethyl N-[2R,3R-(3-hydroxy-2-methyl-3-phenylpropionyl)]-4,4-dimethylpyroglutamate 
• 76549-04-7 (2R,3R)-(+)-3-hydroxy-2-methyl-3-phenylpropanoic acid 
• 100-39-0 benzyl bromide 
• 122-63-4 benzyl proprionate 
• 147253-91-6 N-<(2R,3R)-3-hydroxy-2-methyl-3-phenylpropionyl>-(1S,5R,7R)-10,10-dimethyl-3-thioxo-2-aza-4-oxatricyclo<5.2.1.0^1,5>decane 
• 100-51-6 benzyl alcohol 

Downstream Products

• 76549-05-8 methyl (2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoate 

Relevant articles and documents

A novel DMAP-promoted oxazolidinethione deacylation. Application for the direct conversion of the initial chiral thioimide aldols to various ester protecting groups.

DMAP (4-(dimethylamino)pyridine) promoted nucleophilic cleavage of the initial chiral thioimide aldols can be directed to form various ester protecting groups without causing racemization of the newly created stereocenters.

Chemoselective Nucleophilic Attack on N-Acyl Derivatives of (S)-Ethyl 4,4-Dimethyl Pyroglutamate (DMPG)

(Matrix presented) Heteronucleophiles and C-nucleophiles chemoselectively react with N-acyl (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG) affording esters, amides, and ketones in high yield. The intramolecular process allows the stereoselective formation of β-hydroxy acids likely by formation and ring opening of the corresponding β-lactones.