1363161-14-1

Basic information

• Product Name: ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
• Synonyms: ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
• CAS NO: 1363161-14-1
• Molecular Weight: 404.49
• Mol File: 1363161-14-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate(1363161-14-1)
• EPA Substance Registry System: ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate(1363161-14-1)

Safety Data

• Hazardous Substances Data: 1363161-14-1(Hazardous Substances Data)

Upstream product

• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1363161-15-2 tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate 
• 1625678-19-4 N-(3-(5-methyl-2-S₈(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1625678-21-8 N-(3-(5-methyl-2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1429497-57-3 N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide 
• 1625677-38-4 (2E)-4-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-butenamide 
• 1625678-26-3 N-(3-(2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1625678-28-5 N-(3-(2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1625677-41-9 2-chloro-N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acetamide 
• 1671094-97-5 3-chloro-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide 
• 1625677-42-0 3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide 
• 1625677-43-1 N-(3-(2-((4-((1-acetylazetidin-3-yl)amino)-2-methoxyphenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1625677-45-3 N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide 
• 1610733-05-5 N-(3-(5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 
• 1625677-47-5 N-(3-(2-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

Pyrimidinone compound and composition prepared from pyrimidinone compound

The invention relates to the technical field of chemical medicine, and particularly discloses a pyrimidinone compound, a pharmaceutical composition prepared from the pyrimidinone compound and application of the pyrimidinone compound. The structural formula of the pyrimidinone compound is as follows: the pyrimidinone compound disclosed by the invention can serve as a protease inhibitor and furtherinhibit multiple kinds of tumor cells from growth effectively, generates an inhibiting effect on the protease of EGFR and Her families such as EGFR L858R/T790M and EGFR E745_A750/T790, can be used forpreparing antitumor drugs and overcome drug resistance induced by current drugs. The compound, to which the invention is related, and a pharmaceutically acceptable composition of the compound can beused for preparing the antitumor drugs for mankind and other mammals.

Novel pyrimido-heterocyclic compound and preparation method and application thereof

The invention discloses a novel pyrimido-heterocyclic compound and a preparation method and application thereof. The structure of the pyrimido-heterocyclic compound disclosed by the invention is as shown in a general formula I, and the definitions of all substituents are described in the specification and claims. The pyrimido-heterocyclic compound disclosed by the invention has much better inhibitory activity and selectivity for double-mutant EGFR kinase than the existing AZD-9291, can be used for preparing anti-tumor drugs, and overcomes the defect of drug tolerance of the first generation ofEGFR inhibitor.