1363720-50-6Relevant articles and documents
Z-selective copper-catalyzed asymmetric allylic alkylation with grignard reagents
Giannerini, Massimo,Fananas-Mastral, Martin,Feringa, Ben L.
supporting information; experimental part, p. 4108 - 4111 (2012/04/10)
Allylic gem-dichlorides undergo regio- and enanantioselective (er up to 99:1) copper-catalyzed allylic alkylation with Grignard reagents affording chiral Z-vinyl chlorides. This highly versatile class of synthons can be subjected to Suzuki cross coupling affording optically active Z-alkenes and 1,3-cis,trans dienes.