1363720-94-8

Basic information

• Product Name: 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine
• Synonyms: 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine
• CAS NO: 1363720-94-8
• Molecular Weight: 573.646
• Mol File: 1363720-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine(1363720-94-8)
• EPA Substance Registry System: 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine(1363720-94-8)

Safety Data

• Hazardous Substances Data: 1363720-94-8(Hazardous Substances Data)

Upstream product

• 124-40-3 dimethyl amine 
• 63660-21-9 5-bromo-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 

Downstream Products

• 1363720-98-2 3'-O-(tetra-butyldimethylsilyl)5'-O-(4,4'-dimethyoxytrityl)-N-acetyl-5-dimethylamino-2-deoxycytidine 
• 1363721-00-9 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-5-dimethylamino-2-deoxycytidine 
• 1363720-96-0 ''3'-O-(tetra-butyldimethylsilyl)-5'-O-(4,4-dimethoxytrityl)5-dimethylamino-2'-deoxycytidine'' 
• 1363720-95-9 3'-O-(tetra-butyldimethylsilyl)5'-O-(4,4'-dimethyoxytrityl)-N-acetyl-5-(dimethylamino)-2'-deoxyuridine 

Relevant articles and documents

Synthesis and photooxidation of oligodeoxynucleotides containing 5-dimethylaminocytosine as an efficient hole-trapping site in the positive-charge transfer through DNA duplexes

We have designed and synthesized DNA duplexes containing 5-dimethylaminocytosine (DMAC) to investigate the effects of C(5)-substituted cytosine bases on the transfer and trapping of positive charge (holes) in DNA duplexes. Fluorescence quenching experiments revealed that a DMAC base is more readily one-electron oxidized into a radical cation intermediate as compared with other natural nucleobases. Upon photoirradiation of the duplexes containing DMAC, the photosensitizer-injected hole migrated through the DNA bases and was trapped efficiently at the DMAC sites, where an enhanced oxidative strand cleavage occurred by hot piperidine treatment. The DMAC radical cation formed by hole transfer may undergo specific hydration and subsequent addition of molecular oxygen, thereby leading to its decomposition followed by a predominant strand cleavage at the DMAC site. This remarkable property suggests that the modified cytosine DMAC can function as an efficient hole-trapping site in the positive-charge transfer in DNA duplexes.