63660-21-9

Basic information

• Product Name: 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL)
• Synonyms: 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL);5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-5-broMo-2'-deoxyuridine
• CAS NO: 63660-21-9
• Molecular Formula: C₃₀H₂₉BrN₂O₇
• Molecular Weight: 672.46
• Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides
• Mol File: 63660-21-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 127-130℃
• Appearance: /
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL)(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL)(63660-21-9)
• EPA Substance Registry System: 5'-DMT-5-BROMO-DU PHOSPHORAMIDITE (CHIRAL)(63660-21-9)

Safety Data

• Hazardous Substances Data: 63660-21-9(Hazardous Substances Data)

Usage

Uses

5’-O-(4,4’-Dimethoxytrityl)-5-bromo-2’-deoxyuridine can be used to prepare as potential antivirals, antibacterials, antifungals, and antineoplastics.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 59-14-3 5-bromo-2'-deoxyuridine 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 

Downstream Products

• 168772-55-2 5-bromo-1-<3-O-(2-aminoethyl)-2-deoxy-5-O-<4,4'-dimethoxytrityl>-β-D-erythro-pentofuranosyl>uracil 
• 149725-98-4 5'-O-DMT-5-amino-2'-deoxyuridine 
• 908138-98-7 N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide 
• 194412-07-2 N'-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N,N-dimethyl-formamidine 
• 194412-13-0 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide 
• 149725-99-5 2'-Deoxy-5'-O-(dimethoxytrityl)-5-trifluoroacetamidouridine 
• 194412-10-7 (1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 168772-56-3 C₄₁H₄₁Br₂N₅O₁₂ 
• 1363720-94-8 5'-(4,4'-dimethoxytrityl)-5-dimethylamino-2'-deoxyuridine 

Relevant articles and documents

Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups

5-Hydroxymethylcytosine has recently been characterized as the 'sixth base' in human DNA. To enable research on this DNA modification, we report an improved method for the synthesis of 5-hydroxymethyl-2′-deoxycytidine (5-HOMedC) phosphoramidite for site-specific incorporation into oligonucleotides. To minimize manipulations we employed a temporary protecting group-free 2′-deoxyuridine to 2′-deoxycytidine conversion procedure that utilizes phase transfer catalysis. The desired 5-HOMedC phosphoramidite is obtained in six steps and 24% overall yield from 2′-deoxyuridine.

Evaluation of oligonucleotides with novel modifications

Oligodeoxynucleotides modified with carboxamide linked dimeric nucleotides and an acyclic nucleoside were prepared and investigated for their hybridization properties toward DNA.