1363739-73-4Relevant articles and documents
Synthesis of 5-substituted 2′-deoxyuridine-5′- phosphonate analogues and evaluation of their antiviral activity
Van Poecke, Sara,Sinnaeve, Davy,Martins, Jose C.,Balzarini, Jan,Van Calenbergh, Serge
, p. 256 - 272 (2012/08/08)
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling. An unanticipated anomerization during phosphonate deprotection allowed us to isolate both anomers of the 5-substituted 2′-deoxy-uridine phosphonates and assess their antiviral activity against a broad panel of viruses. Copyright Taylor and Francis Group, LLC.