136465-81-1 Usage
Description
N-(tert-Butyl)decahydroisoquinoline-3-carboxamide is an organic compound with the molecular formula C15H26N2O. It is an off-white solid and is known for its role in the development of pharmaceuticals, particularly as a fragment in HIV-1 protease inhibitors.
Uses
Used in Pharmaceutical Industry:
N-(tert-Butyl)decahydroisoquinoline-3-carboxamide is used as an intermediate in the production of HIV protease inhibitors for the treatment of AIDS. Its chemical structure contributes to the development of these inhibitors, which are crucial in managing the progression of the disease.
Additionally, this compound is used as a fragment in the synthesis of various HIV-1 protease inhibitors that are currently in clinical trials for AIDS treatment. Its presence in these inhibitors highlights its importance in the ongoing research and development of effective treatments for HIV/AIDS.
Check Digit Verification of cas no
The CAS Registry Mumber 136465-81-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,6 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 136465-81:
(8*1)+(7*3)+(6*6)+(5*4)+(4*6)+(3*5)+(2*8)+(1*1)=141
141 % 10 = 1
So 136465-81-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H26N2O/c1-14(2,3)16-13(17)12-8-10-6-4-5-7-11(10)9-15-12/h10-12,15H,4-9H2,1-3H3,(H,16,17)/p+1/t10-,11-,12-/m0/s1
136465-81-1Relevant articles and documents
Synthesis of the HIV-proteinase inhibitor Saquinavir: A challenge for process research
Goehring, Wolfgang,Gokhale, Surendra,Hilpert, Hans,Roessler, Felix,Schlageter, Markus,Vogt, Peter
, p. 532 - 537 (2007/10/03)
The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir (1), a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.
Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines
Houpis, Ioannis N.,Molina, Audrey,Reamer, Robert A.,Lynch, Joseph E.,Volante,Reider, Paul J.
, p. 2593 - 2596 (2007/10/02)
The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.