13677-53-7

Basic information

• Product Name: Benzenemethanol, 4-chloro-a-(2-phenylethenyl)-
• CAS NO: 13677-53-7
• Molecular Formula: C15H13ClO
• Molecular Weight: 244.721
• Mol File: 13677-53-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-chloro-a-(2-phenylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-chloro-a-(2-phenylethenyl)-(13677-53-7)
• EPA Substance Registry System: Benzenemethanol, 4-chloro-a-(2-phenylethenyl)-(13677-53-7)

Safety Data

• Hazardous Substances Data: 13677-53-7(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 100-52-7 benzaldehyde 
• 956-02-5 4'-chlorochalcone 

Downstream Products

• 956-02-5 4'-chlorochalcone 

Relevant articles and documents

Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction

This study reports the first base-promoted aldol–Tishchenko reactions of allylic alcohols with aldehydes initiated by allylic isomerization. The reaction enables the diastereoselective synthesis of a variety of 1,3-diols with three contiguous stereogenic centers. Unlike commonly reported systems, our method allows the use of readily available allylic alcohols as nucleophiles instead of enolizable aldehydes and ketones.

Switchable Chemoselective Transfer Hydrogenations of Unsaturated Carbonyls Using Copper(I) N-Donor Thiolate Clusters

Unsaturated alcohols and saturated carbonyls are important chemical, pharmaceutical, and biochemical intermediates. We herein report an efficient transfer hydrogenation protocol in which conversion of unsaturated carbonyl compounds to either unsaturated alcohols or saturated carbonyls was catalyzed by Cu(I) N-donor thiolate clusters along with changing hydrogen source (isopropanol or butanol) and base (NaOH or K2CO3). Mechanistic studies supported by DFT transition state modeling indicate that such a chemoselectivity can be explained by the relative concentrations of Cu(I) monohydride and protonated Cu(I) hydride complexes in each catalytic system.