136794-87-1

Basic information

• Product Name: NOR-BETA-CIT
• Synonyms: NOR-2-CIT;NOR-BETA-CIT;8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 3-(4-IODOPHENYL), METHYL ESTER, (1R, 2S, 3S, 5S);(-)-2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL) NORTROPANE;(-)-2-BETA-CARBOMETHOXY-3-BETA-(IODOPHENYL)NORTROPANE;NOR-B-CIT \ ANALOG OF DOPAMINE TRANSPORT;(-)-2b-Carbomethoxy-3b-(4-iodophenyl)nortropane;nor-b-CIT
• CAS NO: 136794-87-1
• Molecular Formula: C₁₅H₁₈INO₂
• Molecular Weight: 371.21
• Product Categories: Inhibitors;Neurochemicals
• Mol File: 136794-87-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 412.6°C at 760 mmHg
• Flash Point: 203.3°C
• Appearance: yellow/crystalline
• Density: 1.528g/cm³
• Vapor Pressure: 5.13E-07mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: −20°C
• Solubility: H2O: insoluble
• CAS DataBase Reference: NOR-BETA-CIT(CAS DataBase Reference)
• NIST Chemistry Reference: NOR-BETA-CIT(136794-87-1)
• EPA Substance Registry System: NOR-BETA-CIT(136794-87-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 136794-87-1(Hazardous Substances Data)

Usage

Description

NOR-BETA-CIT, also known as nor-binaltan, is a synthetic compound that serves as an inhibitor of the serotonin (5-HT) transporter. It is characterized by its colorless to yellowish hygroscopic crystal form. Due to its ability to inhibit the serotonin transporter, NOR-BETA-CIT has potential applications in various fields, particularly in the pharmaceutical and medical industries.

Uses

Used in Pharmaceutical Industry:
NOR-BETA-CIT is used as a research chemical for studying the serotonin (5-HT) transporter. Its role in inhibiting the transporter makes it a valuable tool in understanding the mechanisms of serotonin regulation and its implications in various neurological and psychiatric disorders.
Used in Medical Research:
NOR-BETA-CIT is used as a diagnostic and research tool in medical research, particularly in the study of serotonin-related disorders such as depression, anxiety, and obsessive-compulsive disorder. Its ability to inhibit the serotonin transporter can help researchers gain insights into the pathophysiology of these conditions and develop potential therapeutic strategies.
Used in Drug Development:
NOR-BETA-CIT is used as a lead compound in the development of new drugs targeting the serotonin (5-HT) transporter. Its inhibitory properties can be leveraged to create novel therapeutic agents for the treatment of various psychiatric and neurological disorders, potentially improving the efficacy and safety of existing treatments.

InChI:InChI=1/C15H18INO2/c1-19-15(18)14-12(8-11-6-7-13(14)17-11)9-2-4-10(16)5-3-9/h2-5,11-14,17H,6-8H2,1H3

Upstream product

• 53898-68-3 (-)-Win 35981 
• 135416-43-2 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 156496-01-4 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 
• 50373-10-9 methyl ecgonidine 
• 174224-35-2 2β-carbomethoxy-3β-(4'-trimethylsilylphenyl)tropane 
• 17878-43-2 [4-(trimethylsilyl)phenyl]magnesium bromide 
• 50372-80-0 WIN 35,065-2 
• 131479-15-7 (1R,2S,3S,5S)-3-Phenyl-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 

Downstream Products

• 155798-01-9 FE-beta-CIT 
• 155797-99-2 FP-beta-CIT 
• 173378-73-9 N-(3-hydroxypropyl)-2β-carbomethoxy-3β-(4'-iodophenyl)nortropane 
• 156496-01-4 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 
• 848469-54-5 (1R,2S,3S,5S)-3-(4-Thiophen-2-yl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 

Relevant articles and documents

Synthesis and monoamine transporter affinity of new 2β-carbomethoxy- 3β-[aryl or heteroaryl]phenyltropanes

A series of 16 new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropane derivatives was synthesized and evaluated for binding to monoamine transporters. Most of the compounds exhibited nanomolar affinity for the serotonin transporter (SERT). Four compound

Fluoralkenyl nortropanes

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

Synthesis, characterization and in vivo evaluation of (N-((E)-4-[18F]fluorobut-2-EN-1-YL)-2β-carbomethoxy-3β-(4-substitute -phenyl)nortropanes for imaging DAT by PET

-