53898-68-3

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,3-phenyl-,methyl ester,(1R,2S,3S,5S)-
• CAS NO: 53898-68-3
• Molecular Weight: 245.321
• Mol File: 53898-68-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,3-phenyl-,methyl ester,(1R,2S,3S,5S)- (CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,3-phenyl-,methyl ester,(1R,2S,3S,5S)- (53898-68-3)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid,3-phenyl-,methyl ester,(1R,2S,3S,5S)- (53898-68-3)

Safety Data

• Hazardous Substances Data: 53898-68-3(Hazardous Substances Data)

Upstream product

• 50373-10-9 methyl ecgonidine 
• 50372-80-0 WIN 35,065-2 
• 131479-15-7 (1R,2S,3S,5S)-3-Phenyl-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 

Downstream Products

• 1179817-49-2 methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate 
• 1179817-58-3 methyl 8-(((1R,2R)-2-(fluoromethyl)cyclopropyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate 
• 1179817-53-8 methyl 8-(((1S,2S)-2-(fluoromethyl)cyclopropyl)methyl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate 
• 136794-87-1 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and monoamine uptake inhibition of conformationally constrained 2β-carbomethoxy-3β-phenyl tropanes

A series of 2β-carbomethoxy-3β-phenyl tropanes with conformationally constrained nitrogen substituents were synthesized as potential selective dopamine transporter ligands. These novel compounds were examined for their monoamine uptake inhibition potency at the human dopamine transporter (hDAT), the human serotonin transporter (hSERT) and the human noradrenalin transporter (hNET), stably expressed in human embryonic kidney cells (HEK). A SAR-study was conducted to determine the contribution of extended, 4-fluorinated, conformationally constrained C4 chains at the tropane nitrogen to human monoamine transporter affinity and selectivity. The Royal Society of Chemistry 2009.

Synthesis, characterization and in vivo evaluation of (N-((E)-4-[18F]fluorobut-2-EN-1-YL)-2β-carbomethoxy-3β-(4-substitute -phenyl)nortropanes for imaging DAT by PET

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[123I]-2β-carbomethyoxy-3β-(4-iodophenyl)tropane: High-affinity SPECT radiotracer of monoamine reuptake sites in brain [3]

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