137089-36-2 Usage
Description
2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide, also known as (E)-N-[2-[(2-Cyclohexylethyl)thio]ethyl]-2-decenamide, is a chemical compound with potential applications in the pharmaceutical industry. It is characterized by its unique structure, which includes a decenoyl group, a cyclohexylethyl group, and a sulfide bond. 2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide is known for its anti-ulcerogenic properties and low toxicity, making it a promising candidate for the development of treatments for ulcers.
Uses
Used in Pharmaceutical Industry:
2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide is used as an anti-ulcerogenic agent for the treatment of stress-induced ulcers. Its application is based on its ability to inhibit the development of ulcers and maintain the balance of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. This suggests that the compound could be effective in managing and preventing ulcers caused by stress, potentially offering a safer and more targeted treatment option for patients suffering from this condition.
Check Digit Verification of cas no
The CAS Registry Mumber 137089-36-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,0,8 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 137089-36:
(8*1)+(7*3)+(6*7)+(5*0)+(4*8)+(3*9)+(2*3)+(1*6)=142
142 % 10 = 2
So 137089-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H37NOS/c1-2-3-4-5-6-7-11-14-20(22)21-16-18-23-17-15-19-12-9-8-10-13-19/h11,14,19H,2-10,12-13,15-18H2,1H3,(H,21,22)/b14-11+
137089-36-2Relevant articles and documents
Inhibitory effect of 2-(E-2-alkenoylamino)ethyl alkyl sulfides on gastric ulceration in rats. II. Structure and activity relationships of 2(E-n or Z-n-decenoylamino)ethyl alkyl sulfides
Kohda,Iwai,Watanabe,Arakawa,Fukaya,Yokoyama,Kohama,Mimura
, p. 1546 - 1550 (2007/10/02)
The analogues of 2-(E-n or Z-n-decenoylamino)ethyl carbamoylmethyl sulfide, including the modifications of sulfide portion, double bond in decenoyl chain and alkyl sulfide moiety, were synthesized and their inhibitory effects on stress-induced ulceration in rats were compared. Replacing the sulfura atom by methylene group or oxygen atom reduced the effect of potency. Saturation of the double bond in the decenoyl chain tended to reduce the anti-ulcerogenic activity in rats. There was no relationship between the position of double bond in decenoyl chain and the pharmacological activity. On the other hand, compounds with E-configuration showed stronger anti-ulcer activity than the corresponding Z-type of compounds. Among 9 kinds of S substituted alkyl groups for carbamoylmethyl, 2-(E-2-decenoylamino)ethyl 2-cyclohexylethyl sulfide showed the most potent anti-ulcerogenic activity in rats and also showed the lowest acute toxicity in mice.
