1379537-19-5Relevant articles and documents
A highly diastereoselective decarboxylative mannich reaction of β-keto acids with optically active N-sulfinyl α-imino esters
Yang, Cui-Feng,Shen, Chen,Wang, Jian-Yong,Tian, Shi-Kai
, p. 3092 - 3095 (2012/08/28)
A range of protected γ-oxo-α-amino esters have been prepared in a highly regio- and stereoselective manner through the decarboxylative Mannich reaction of β-keto acids with optically active N-tert-butanesulfinyl α-imino esters in the presence of 3 mol % La(OTf)3 or 5 mol % Y(OTf)3 at 20 °C. Preliminary mechanistic studies indicate that the reaction proceeds through imine addition followed by decarboxylation.
