137976-75-1

Basic information

• Product Name: 5H-1-Benzazepin-5-one, 1-(4-amino-2-methoxybenzoyl)-7-chloro-1,2,3,4-tetrahydro-
• CAS NO: 137976-75-1
• Molecular Formula: C18H17ClN2O3
• Molecular Weight: 344.798
• Mol File: 137976-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5H-1-Benzazepin-5-one, 1-(4-amino-2-methoxybenzoyl)-7-chloro-1,2,3,4-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1-Benzazepin-5-one, 1-(4-amino-2-methoxybenzoyl)-7-chloro-1,2,3,4-tetrahydro-(137976-75-1)
• EPA Substance Registry System: 5H-1-Benzazepin-5-one, 1-(4-amino-2-methoxybenzoyl)-7-chloro-1,2,3,4-tetrahydro-(137976-75-1)

Safety Data

• Hazardous Substances Data: 137976-75-1(Hazardous Substances Data)

Upstream product

• 247237-43-0 methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate 
• 193686-76-9 7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 247237-38-3 N-p-toluenesulfonyl-5-chloro-anthranilic acid methyl ester 
• 160129-45-3 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 39787-83-2 2-methoxy-4-nitrobenzoyl chloride 
• 2597-56-0 4-nitro-o-anisic acid 
• 51282-49-6 methyl 5-chloro-2-nitrobenzoate 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 247237-91-8 7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 

Downstream Products

• 137974-15-3 7-chloro-1-[2-methoxy-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.